Peer Consultation on the Scientific Rationale for Approaches to
Derive Database and Toxicodynamic Uncertainty Factors to Protect
September 19, 2005, 8:30am - 5:00pm
Where: Northern Kentucky University Metropolitan
Education and Training Services (METS),
goal of the peer consultation was to obtain expert input on the scientific
rationale for selection of uncertainty factors
to address issues associated with developmental, neonatal, child, or
reproductive toxicity studies when deriving reference doses (RfDs).
Two distinct data
compilations were discussed. The
first compilation related to the current procedure for deriving human
RfDs when no adequate human or animal reproductive or developmental
studies are available. The
panel discussed the database uncertainty factor, developed by EPA in
the late 1980s and based largely on pesticide studies, in light of
additional human and experimental animal toxicity data for diverse classes
of chemicals and exposure routes. The
second compilation related to the scientific
rationale for making animal-to-human extrapolations of developmental,
neonatal, or reproductive endpoints that are reported as critical effects
in experimental animal studies. The
panel explored approaches for applying chemical specific adjustment
factors (CSAFs) for toxicodynamics based on known similarities and
differences in physiology and anatomy.
Both of these compilations have
usefulness for uncertainty factor selection when deriving RfDs.
TERA Contact: Dr. Dan Briggs: phone 231-276-0126; email firstname.lastname@example.org
Alternate Contact: Ms.
Jacqueline Patterson: 513-521-7426;email email@example.com