scientific peer review of a toxicological review and assessment for
acrylonitrile was held on
September 22-23, 2003
Ohio. The meeting was held at the
and was open to the public. An
independent Peer Review Panel reviewed an assessment that included
derivation of oral and inhalation risk values, utilizing the best
available science and current risk assessment methods and guidelines. The
Sapphire Group, Inc. on behalf of the Acrylonitrile Group prepared the
assessment document. This independent peer review meeting was held under
the International Toxicity Estimates for Risk (ITER)
program of Toxicology Excellence for Risk Assessment (TERA).
is a building block chemical used to make numerous products, including
acrylic fiber for clothing, blankets, carpeting and other fabrics; rugged
plastics for computer and TV housings; and nitrile rubber for
oil-resistant hoses. Acrylonitrile
is also identified as a Hazardous Air Pollutant and as such the U.S.
Environmental Protection Agency (EPA) must consider the need to adopt
various Clean Air Act regulations to reduce emissions. The assessment
presented builds on EPA’s 1983 risk assessment which is currently
reflected in the Agency’s Integrated Risk Information System (IRIS), but
also incorporates the significant new information and methodologies that
have been generated since that time. The
objective of this peer review was to review the updated scientific
assessment of acrylonitrile and the risk values presented.
Post-Meeting Information and Documentation
The Sapphire Group Inc. and the Acrylonitrile Group revised their assessment document in response to the peer review.
A summary of the risk values and assessment for acrylonitrile are available on the International Toxicity Estimates for Risk database.
Link to ITER