ARA
About the Framework    
   ǀ      FAQ        ǀ    


ARA Dose-Response Framework >

Problem Formulation
 > Qualitative


 

 


Assemble Health Effects Data


Endpoint Assessment

  • Use available data to identify adverse effects, focusing on those of concern for exposed populations
  • Consider strengths and uncertainties in data

 






MOA Assessment

  • What are expected targets, based on chemical structure, available data, and related chemicals?
  • What is known about MOA for related chemicals?

 

 






Vulnerable Populations

  • Assessment
  • Use available data to assist in the risk management
    decision











Background Exposure Assessment

  • Use available data to assist in the risk management decision






 

Integration

Results Reporting

___________________________________________________________________________________________________________________________________

Problem Formulation > Qualitative > Integration

 

 

 

 

 

Case Studies In-Hand

expand Uncertainty Factors Distributions for Risk Above the RfD
expand Value of Information: Approach and Case Studies 
  • Value of Information: Approach and Case Studies 
    Eric Ruder, Henry Roman

expand Sustainable Futures Screening Method
expand Low Dose Extrapolation from the BMD(L)
  • Implications of Linear Low-Dose Extrapolation from Benchmark Dose for Noncancer Risk Assessment 
    Kroner O., Haber L.
    Advisor: Dourson M.

expand Screening Tools for the Interpretation of Chemical Biomonitoring Data
 

 

 

 

   

___________________________________________________________________________________________________________________________________

 

Questions? Suggestions? Please send your feedback to tera@tera.org.