Toxicology Excellence for Risk Assessment (TERA)

2300 Montana Avenue, Suite 409, Cincinnati OH 45211
Phone: 513-542-7475
Fax: 513-542-7487

Email:
TERA@TERA.org

  TERA Staff Publications

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The following publications are in alphabetical order by first author, with the exception of TERA reports, which are at the bottom of this list.  Click the appropriate letter to go to the desired section of the list.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Abernathy, C.O. and M.L. Dourson. 1994. Derivation of the inorganic arsenic Reference Dose. In: Arsenic Exposure and Health. W.R. Chappell, C.O. Abernathy and C.R. Cothern (editors). Science and Technology Letters, Northwood, England.

Araya, M., B. Chen, L. Klevay, J. Strain, L. Johnson, P. Robson, W. Shi, F. Neilsen, H. Zhu, M. Olivares, F. Pizarro and L. Haber.  2003.  Confirmation of an Acute No-Observed-Adverse-Effect Level (NOAEL) and Low-Observed-Adverse-Effect Level (LOAEL) for Copper in Bottled Drinking Water in a Multi-site International Study. Regul. Toxicol. Pharmacol. 38(3):389-99.

Araya, M., M.C. McGoldrick, L. Klevay, J.J. Strain, P. Robson, F. Nielsen, M. Olivares, F. Pizarro, L. Johnson and K.A. Poirier. 2001.  Determination of an Acute No-Observed-Adverse-Effect Level (NOAEL) for Copper in Water.  2001. Reg. Toxicol. Pharmacol.  34:137-145.

Barnes, D.G. and M. Dourson. 1988. Reference dose (RfD): Description and use in health risk assessment. Reg. Tox. Pharmacol. 8: 471-486.  Russian edition

Beck, B. and M. Dourson. 1993. How toxicity data are used in the process of hazard identification and dose-response assessment. In: Basic Risk Assessment: Current Developments. Society of Toxicology Continuing Education Course #6, 32nd Annual Meeting, New Orleans, LA, March 14.

Beck, B.D., R.B. Conolly, M.L. Dourson, D. Guth, D. Hattis, C. Kimmel and S.C. Lewis. 1993. Improvements in quantitative noncancer risk assessment. Fund. Appl. Toxicol. 20: 1-14.

Boyes, W.K., M.L. Dourson, J. Patterson, H.A. Tilson, W.F. Sette, R.C. Macphail, A.A. Li and L.L. O’Donoghue. 1997. Workshop Overview: EPA’s Neurotoxicity Risk Assessment Guidelines. Fund. Appl. Toxicol. 40 (2):175-184.

Briggs, D. and W. George.  1977.  The Metabolism of Erythropoietin, in Kidney Hormones, Vol. II, 73-109, Acad. Press.

Briggs, D., L. Condie and T. Tephley.  1976.  Delta-Amino-Levulinic Acid Synthetase in the Heart.   J. Biol. Chem. 251, 4996-5001.

Charnley, G. and J. Patterson.  2003.  Review of Procedures for Protecting Human Subjects in Recent Clinical Studies of Pesticides.  Reg. Toxicol. and Pharmacol.  38: 210-223.

Charnley, G. and J. Patterson.  2003.  Use of Human Subjects Data for Regulating Chemical Exposure.  Environmental Law Reporter.

DeRosa, C.T., M.L. Dourson and R. Osborne. 1989. Risk assessment initiatives for noncancer endpoints: Implications for risk characterizations of chemical mixtures. Tox. Ind. Health 5(5): 805-824.

Dolan, D., B. Naumann, E. Sargent, A. Maier, M. Dourson.  2005. Application of the threshold of toxicological concern concept to pharmaceutical manufacturing operations.  Reg. Toxicol. Pharmacol. 43: 1-9.

Dourson, M.L., R. Hertzberg, B. Allen, L. Haber, A. Parker, O. Kroner, A. Maier, and M. Kohrman.  2008.  Evidence-Based Dose Response Assessment for Thyroid Tumorigenesis from Acrylamide.  Accepted for publication.

Dourson, M.L. and Parker, A. 2007. Past and Future Use of Default Assumptions and Uncertainty Factors: Default Assumptions, Misunderstandings, and New Concepts. Hum Ecol Risk Assess. 13(1):82-88.

Dourson, M and D. Drinan.  2006.  Sensitive Populations and Risk Assessment. In: Toxicokinetics in Risk Assessment. Taylor and Francis Publishers. J.C. Lipscomb and E.V. Ohanian, Eds.  Informa health care, New York.  Pp. 251-210.

Dourson, M.L., Q. Zhao, C.E. Hack and A.L. Parker.  2005.  Trichloroethylene Dose Response Assessment: Additional Issues Relevant for a Scientifically Credible Approach.  White Paper

Dourson, M. and J. Patterson.  2003.  A 20-Year Perspective on the Development of Non-Cancer Risk Assessment Methods. Special issue of the Journal of Human and Ecological Risk Assessment commemorating 20th anniversary of the NRC’s Red Book on risk assessment and risk management. Human and Ecological Risk Assessment, 9: 1239-1252.

Dourson et al.  2002.  Comparative Dietary Risk:  Balance the Risk and Benefits of Fish Consumption.  Comments on Toxicology  8:335-536.  See the TERA report in it entirety below under TERA Reports  

Dourson, M.L., G. Charnley and R. Scheuplein.  2002.  Differential Sensitivity of Children and Adults to Chemical Toxicity:  II.  Risk and Regulation.  Reg. Tox. Pharmacol.  35:448-467.

Dourson, M. and M.Younes.  2002.  Evolution in noncancer risk assessment - current practice, controversies, and challenges.  Comments on Toxicology. 7(5-6):399-414

Dourson, M., M. Andersen, L. Erdreich and J. MacGregor.  2001.  Using human data to protect the public’s health.  Reg. Toxicol. Pharmacol., Vol. 33, No. 2, Apr 2001, pp. 234-256. (doi:10.1006/rtph.2001.1469)

Dourson, M. and L. Erdreich.  2001.  Using Human Data to Develop Risk Values.  Hum. Ecol. Risk Assess.  Vol. 7, No. 6.

Dourson, M.L,  A.E. Wullenweber and K.A. Poirier.  2001.  Uncertainties in the Reference Dose for Methylmercury, NeuroToxicology 22 (5) (2001) pp. 677-689.

Dourson, M.L., A. Maier, B. Meek, A. Renwick, E. Ohanian and K. Poirier. 1998. Re-evaluation of toxicokinetics for data-derived uncertainty factors. Biol. Trace Element Res. 66: 453-463.

Dourson, M.L. and S.P. Felter. 1997. Route-to-route extrapolation of the toxic potency of MTBE. Risk Anal., 25: 43-57.

Dourson, M.L., L.K. Teuschler, P.R. Durkin and W.M. Stiteler. 1997. Categorical regression of toxicity data: a case study using aldicarb.  Reg. Toxicol. Pharmacol. 25: 121-129.

Dourson, M.L. 1996. Editorial: Uncertainty Factors in noncancer Risk Assessment. Reg. Tox. Pharmacol. 24. Article No. 0115. p. 107.

Dourson, M.L. 1995. How Regulatory Agencies View Biological Effects of Low Level Exposures. BELLE Newsletter. 4(1):7.

Dourson, M.L. 1994. Methods for establishing oral reference doses (RfDs). In: Risk Assessment of Essential Elements, W. Mertz, C.O. Abernathy and S.S. Olin, Ed. ILSI Press, Washington, DC. pp. 51-61.

Dourson, M.L. 1994. The chromium reference doses (RfDs). In: Risk Assessment of Essential Elements, W. Mertz, C.O. Abernathy and S.S. Olin, Ed. ILSI Press, Washington, DC.

Dourson, M.L. 1993. Reference dose of the United States Environmental Protection Agency. Scand. J. Work Environ. Health 19 (Suppl. 1): 115-118.

Dourson, M.L. 1993. Modifying uncertainty factors for noncancer endpoints. In: Advanced Topics in Risk Assessment. Society of Toxicology Continuing Education Course #10. 32nd Annual Meeting, New Orleans, LA, March 14.

Dourson, M.L. 1991. Overview of EPA's quantitative noncancer guidelines. Air and Waste Management Association. In: 84th Annual Meeting & Exhibition, Vancouver, British Columbia, June 16-21. pp 2-7.

Dourson, M.L., B. Stern, S. Griffin and K. Bailey. 1991. Impact of risk-related concerns on U.S. Environmental Protection Agency Programs. In: Nitrate Contamination: Exposure, Consequence and Control, I. Bogardi and R.O. Kuzella, Ed. NATO ASI Series G: Ecological Sciences, Vol. 30.

Dourson, M.L. and J.M. Clark. 1990. Fish consumption advisories: Toward a unified, scientifically credible approach. Reg. Tox. Pharmacol. 12: 165-172.

Dourson, M.L. 1986. New approaches in the derivation of the acceptable daily intake (ADI). Comments Toxicol. 1: 35-48.

Dourson, M.L. and C.S. Baxter. 1981. Reduced prevalence and growth rate of urethane induced lung adenomas in aging adult strain A mice. Toxicology 20: 165-172.

Dourson, M.L., S.P. Felter and D. Robinson. 1996. Evolution of science-based uncertainty factors in noncancer risk assessment. Reg. Tox. Pharmacol., 24: 108-120.

Dourson, M.L. and E.J. O'Flaherty. 1982. Relationship of lung adenoma prevalence and growth rate to acute urethane dose and target cell number. J. Natl. Cancer Inst. 69(4):851-857.

Dourson, M.L. and F.C. Lu. 1995. Safety/Risk assessment of chemicals compared for different expert groups. Biomedical and Environmental Sciences 8:1-13.

Dourson, M.L., L. Knauf and J. Swartout. 1992. On reference dose (RfD) and its underlying toxicity database. Tox. Ind. Health 8(3): 171-189.

Dourson, M.L. and C.T. DeRosa. 1991. The use of uncertainty factors in establishing safe levels of exposure. In: Statistics in Toxicology, D. Krewski and C. Franklin, Ed. Gordon and Breach Science Publishers, New York, NY.

Dourson, M.L. and W.L. Jordan. 1989. How "safe" is the ground water Americans drink? Ground Water Monitoring Report Fall: 73-74.

Dourson, M.L., R.C. Hertzberg and J.F. Stara. 1986. Letters to the Editor. Fund. Appl. Toxicol. 6: 182-184.  

Dourson, M.L., R. Hertzberg, R. Hartung and K. Blackburn. 1985. Novel methods for the estimation of acceptable daily intake. Tox. Ind. Health 1: 23-33.

Dourson, M.L. 1984. Toxicity-based methodology, thresholds and possible approaches, and uncertainty factors. In: Approaches to Risk Assessment for Multiple Chemical Exposures. EPA 600/9-84-008. p. 2-42.

Dourson, M.L. 1984. Health risk assessment for less-than-lifetime chemical exposure - toxicants and carcinogens. In: Selected Approaches to Risk Assessment for Multiple Chemical Exposures: Progress Report on Guideline Development at ECAO-Cin, J.F. Stara and L.S. Erdreich, Ed. U.S. EPA, Cincinnati, OH EPA 600/9-84/014a. p. 9-15.

Dourson, M.L. and J. Stara. 1983. Regulatory history and experimental support of uncertainty (safety) factors. Reg. Tox. Pharmacol. 3: 224-238.

Edler, L., K. Poirier, M. Dourson, J. Kleiner, B. Mileson, H. Nordmann, A. Renwick, W. Slob, K. Walton and G. Wurtzen.  2002.  Mathematical Modelling and Quantitative Methods.  Food and Chemical Toxicology.  40: 283-326.

Farland, W. and M.L. Dourson. 1992. Noncancer health endpoints: Approaches to quantitative risk assessment. In: Comparative Environmental Risk Assessment, R. Cothern, Ed. Lewis Publishers Inc., Boca Raton, LA. December.

Felter, S.P. and M. Dourson. 1998. The Inexact Science of Risk Assessment (and Implications for Risk Management). Human and Ecol. Risk Assessment: Vol. 4(2): 245-251.

Felter, S.P. and J.S. Dollarhide. 1997. Acrylonitrile: A Reevaluation of the Database to Support an Inhalation Cancer Risk Assessment. Reg. Tox. Pharmacol. 26: 281-287.

Felter, S.P. and M.L. Dourson. 1997. Hexavalent chromium contaminated soils: Options for risk assessment and risk management. Reg. Tox. Pharmacol. 25: 43-59.

Felter, S.P., M. Dourson and J. Patterson. 1997. Chapter 2: Assessing Risks to Human Health from Chemicals in the Environment. In: Handbook of Environmental Risk Assessment & Management. P. Calow, Ed. Blackwell Science, Oxford. 9-23.

Felter, S.P. and J.S. Dollarhide. 1997. Acrylonitrile: A Reevaluation of the Database to Support an Inhalation Cancer Risk Assessment. Reg. Tox. Pharmacol. 26: 281-287.

Fields, C., M.L. Dourson and J. Borak.  2005.  Iodine-deficient vegetarians: A hypothetical perchlorate-susceptible population?  Reg. Tox. Pharmacol..  June,  42(1): 37-46.

Flaherty, E.J. and M.L. Dourson. 1983. A reply to the letter to the Editor "Cells of Origin of Lung Tumors in Mice". J. Natl. Cancer Inst. 70(6): 991-992.

Fry, B. and D. Briggs.  1980.  Uniform Distribution of Fluoride and Calcium in Bones from Dogs, J. Dental Research, 59A: 525  (1024).

Gadagbui, B.K., L.T. Haber and M.L. Dourson. 2006.  Chemical Risk Assessment as Used in Setting Regulatory Levels or Standards.  Chap. 3.3.1 in Transforming Sustainability Strategy into Action: The Chemical Industry, edited by Beth Beloff, Marianne Lines, and Dicksen Tanzil. Hoboken , NJ : John Wiley & Sons, Inc., 2005.

Gentry, P.R., Haber, L.T., McDonald, T.B., Zhao, Q. Covington, T., Nance, P., Clewell III, H.J., Lipscomb, J.C., and Barton, H.A. 2004. Data for physiologically based pharmacokinetic modeling in neonatal animals: Physiological parameters in mice and Sprague-Dawley rats. Journal of Children's Health. 2(3-4): 363-412.

Gentry, P.R., C.E. Hack, L. Haber, A. Maier and H.J. Clewell, 3rd. 2002. An Approach for the Quantitative Consideration of Genetic Polymorphism Data in Chemical Risk Assessment: Examples with Warfarin and Parathion. Toxicol Sci. Nov, 70(1):120-39.  (Please note: Haber et al. 2002 describes phase 1 of this project.)

Haber, L.T.  2006.  Overview of Approach to Noncancer Risk Assessment.  In:  Toxicokinetics in Risk Assessment, Taylor and Francis publishers, J.C. Lipscomb and E.V. Ohanian, eds.  Informa health care, New York.  Pp. 1-26.

Haber, L., Maier, A., and Dourson, M. 2006. Using Best Science in Cancer Risk Assessment, Editorial.  Hum Ecol Risk Assess 12(1):1-8.

Haber, L.T. and J. Patterson.  2005.  Report of an Independent Peer Review of an Acrylonitrile Risk Assessment.  Human & Exp. Tox. 24(10): 487-527.

Haber, L.T. and A. Maier.  2002.  Scientific Criteria used for the Development of Occupational Exposure Limits for Metals and Other Mining-Related Chemicals.  Reg. Toxicol. Pharmacol.  36(3): 262-279

Haber, L.T., A. Maier, P.R. Gentry, H.J. Clewell and M.L. Dourson.  2002.  Genetic Polymorphisms in assessing interindividual variability in delivered dose.  Regulatory Toxicology and Pharmacology 35, 177-197.  (Please note: Gentry et al. 2002 is the companion follow-up paper)

Haber, L.T., J.S. Dollarhide, A. Maier and M.L. Dourson. 2001. Noncancer Risk Assessment: Principles and Practice in Environmental and Occupational Settings. In: Patty’s Toxicology, Fifth edition. Bingham, E., Cohrssen, and C.H. Powell, ed. Wiley and Sons, Inc.

Haber, L.T., A. Maier, Q. Zhao, J.S. Dollarhide, R.E. Savage and M.L. Dourson. 2001 Applications of Mechanistic Data in Risk Assessment -- The Past, Present, and Future.  Toxicological Sciences.  61(1): 32-39.

Lynne Haber; Patricia Nance; Andrew Maier; Paul Price; Eugene Olajos; Larry Bickford; Maureen McConnell; B. J. Klauenberg;  2007.   Human Effectiveness and Risk Characterization of Oleoresin Capsicum (OC) and Pelargonic Acid Vanillylamide (PAVA or Nonivamide) Hand-Held Devices.  Storming Media.

Haber, L., J. A. Strickland and D. J. Guth. 2001.  Categorical Regression Analysis of Toxicity Data. Comments on Toxicology. 7(5-6):437-452.

Haber, L.T., G.L. Diamond, G.L. Q. Zhao, L. Erdreich and M.L. Dourson (2000). Hazard identification and dose-response of ingested nickel soluble salts. Reg. Tox. Pharmacol, 31: 231-241.

Haber, L.T., L. Erdreich, G.L. Diamond, A.M. Maier, R. Ratney, Q. Zhao and M.L. Dourson (2000). Hazard identification and dose-response of inhaled nickel soluble salts. Reg. Tox. Pharmacol, 31:  210-230.

Haber, L.T., B. Allen and C. Kimmel. 1998. Noncancer risk assessment for nickel compounds: issues associated with dose-response modeling of inhalation and oral exposures. Toxicological Sciences. 43: 213-229.

Hack, C. Eric. 2006. Bayesian analysis of physiologically based toxicokinetic and toxicodynamic models. Toxicology 221(2-3):241-248.

Hack, C.E., Haber, L.T., Maier, A., Schulte, P., Fowler, B., Lotz, W.G., AND Savage, R.E.  2006.  A Method for Biomarker Validation and Biomarker-based Dose Response:  A Case Study with Benzene and a Bayesian Network.  Submitted. 

Hack, C.E., W.A. Chiu, Q.Zhao, and H.J. CLewell.  2006.  Bayesian Population Analysis of a Harmonized Physiologically-based Pharmacokinetic Model of Trichloroethylene and its Metabolites.  Reg. Tox. Pharm. 46:63-83.

Hakkinen, P.J. (2002). Human Exposure to Substances Contained in Cleaning Products. In: Proceedings of the "Risks from Chemicals Released from Consumer Products/Articles" Workshop, European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Physical and Chemical Exposure Unit, Ispra, Italy (June 17 2002), pp.31-34.

Hakkinen, P.J. and D.K. Green.  2002.  Alternatives to Animal Testing: Information Resources via the Internet and World Wide Web. Web. Toxicol. 173: 3-11.

Hakkinen, P. J.  2001. Global Toxicology and Risk Analysis: Roles of the Internet and World Wide Web. Toxicology 160: 59-63.  

Hakkinen, P.J.  2000. Toxicology Testing Methods and Laboratories. In: Information Resources in Toxicology. P. Wexler, P.J. Hakkinen, G. Kennedy, Jr., and F.W. Stoss (editors)Academic Press, San Diego, CA.

Hasegawa R, Hirata-Koizumi M, Dourson M, Parker A, Hirose A, Nakai S, Kamata E, Ema M. 2007. Pediatric susceptibility to 18 industrial chemicals: A comparative analysis of newborn with young animals. Regul Toxicol Pharmacol. 47(3):296-307.  Available at:  http://www.elsevier.com/wps/find/journaldescription.cws_home/622939/description?navopenmenu=-2

Hertzberg, R.C. and M.L. Dourson. 1993. Using categorical regression instead of a NOAEL to characterize a toxicologist's judgment in noncancer risk assessment. In: Toxicology of Chemical Mixtures: Case Studies, Mechanisms and Novel Approaches, R.S.H. Yang, Ed. Academic Press, San Diego, CA.

Hertzberg, R.C. and J. Patterson. 1987. Approaches to the Quantitative Estimation of Health Risk from Exposure to Chemical Mixtures. In: Health & Environmental Research on Complex Organic Mixtures, (R.H. Gray, E.K. Chess, P.J. Mellinger, R.G. Riley and D.L. Springer, Eds.) Twenty-Fourth Handford Life Sciences Symposium, October 20-24, 1985. p. 747-757.

Hiles, R.,  J. Franxman, C. Weiskittel and D. Briggs.  1978.  Effect of Nutrient Toxicities in Animals and Man: Tin, in CRC Handbook Series in Nutrition and Food, Section E: Nutritional Disorders, Vol. 1, 349-363, CRC Press.

Jarabek, A.M., M.G. Menache, J.H. Overton, Jr., M.L. Dourson and F.J. Miller. 1989. Inhalation reference dose (RfD): An application of interspecies dosimetry modeling for risk assessment of insoluble particles. Health Phys. 57(Suppl. 1): 177-183.

Jarabek, A.M., M.G. Menache, J.H. Overton, Jr., M.L. Dourson and F.J. Miller. 1990. The U.S. Environmental Protection Agency's inhalation RfD methodology: Risk assessment for air toxics. Tox. Ind. Health 6(5): 279-301.

Knuth, B.A., N.A. Connelly, J. Sheeshka and J. Patterson. 2003.  Weighing Health Benefit and Health Risk Information when Consuming Sport-caught Fish.  Risk Analysis.  23(6):1185-1197.

Lakind, Judy, Robert Brent, Michael Dourson, Sam Kacew, Gideon Koren, Babasaheb Sonawane, Anita Tarzian, Kathleen Uhl.  2005.  Human Milk Biomonitoring Data: Interpretation and Risk Assessment Issues.  Journal of Toxicology and Environmental Health, vol. 68, no. 20.

Lakind, J.S., M.E. Ginevan, D.Q. Naiman, A.C. James, R.A. Jenkins, M.L. Dourson, S.P. Felter, C.G. Graves and R.G. Tardiff. 1999. Distribution of exposure concentrations and doses for constituents of environmental tobacco smoke. In: Risk Analysis. 19(3): 375-390.

Lee, S.D., M.L. Dourson, D. Mukerjee, J.F. Stara and J. Kawecki. 1983. Assessment of benzene health effects in ambient water. In: Carcinogenicity and toxicity of benzene, M.A. Mehlman (Editor), Princeton Scientific Publisher, Inc., Princeton, NJ. pp 91-125.

Lipscomb, J. C., M. Meek, K. Krishnan, G.L. Kedderis, H. Clewell and L.T. Haber. 2004.  Incorporation of Pharmacokinetic and Pharmacodynamic Data into Risk Assessments.  Toxicol. Mech. Methods.  14:145-158.

Lu, F.C. and M.L. Dourson. 1992. Safety risk assessment of chemicals: Principles, procedures and examples. J. Occup. Med. Tox. 1(4): 321-335.  Chinese edition

Lu, F.C. and M.L. Dourson. 1992. Safety/risk assessment of pesticides: Principles, procedures and examples. Toxicol. Lett. 64/65: 783-787.

Leikauf, G. D., Q. Zhao, S. Zhou and J. Samtrock. 1993. Ozonolysis products of membrane fatty acids activate eicosanoid metabolism in human airway epithelial cells. Am. Respir. Cell. Mol. Biol. 9:594-602.

 

Leikauf, G. D., L. G. Simpson, J. Santrock, Q. Zhao, J. Abbinante-Nissen, S. Zhou and K. E. Driscoll. 1995. Airway epithelial cell responses to ozone injury. Environ. Health Perspec. 103: suppl. 2:91-95.

Maier, A., B. Gadagbui, E. Hack, Q. Zhao, A. Parker, A. Weinrich, and C. Geraci.  2006. Use of Animal Acute Toxicity Data to Derive Immediately Dangerous to Life or Health Concentrations: Extrapolating to Human Effect Thresholds.  In preparation.

Maier, A. and L.T. Haber.  2006.  Toward the Goal of Harmonizing Occupational Exposure Limits: Approaches for Enhancing Derivation Methods.  In preparation.

Maier, A., E. Hack, Q. Zhao, L.T. Haber and M.L. Dourson.  2006.  Derivation of an Occupational Exposure Limit for Inorganic Borates using a Weight of Evidence Approach.  In preparation.

Maier, A., C. Sherry, P. Reilly, P. Price.  2005.  Human Effectiveness and Risk Characterization for Electromuscular Disruption Devices.  NATO Press.  In Press

Maier, A, R.E. Savage and L.T.Haber. 2004. Assessing biomarker use in risk assessment - A survey of practitioners. Journal of Toxicology and Environmental Health Part A. 67(8-10):687-695.

Maier, A., R.E. Savage, JR. and  L.T. Haber.  2004.  Linking Exposure to Effect:  Are Biomarker Spectra Providing a Clearer Vision for Risk Assessment.  J. Toxicol. Environ. Health. Part A. 67(8-10):687-695.

Maier, A., B.L. Schumann, X. Chang, G. Talaska and A. Puga.  2002.  Arsenic coexposure potentiates Benzo(a)pyrene Genotoxicity.  Mut. Res. Genet. Toxicol. Environ. Mutagen.  517(1-2): 101-111.

Maier, A., D.G. DeBoard and R.E. Savage, JR.  2001.  Incorporating biomarkers into 21st century risk assessments. Comments on Toxicology. 7(5-6):519-539.  

Maier, A., T. Dalton and A. Puga.  2000.  Disruption of Dioxin-Inducible Phase I and Phase II Gene Expression Patterns by Cadmium, Chromium , and Arsenic.  In:  Molecular Carcinogenesis.  28:225-235.

Maier, A., J. Micka, K. Miller, T. Denko, C.Y. Chang, D.W. Nebert, A. Puga.  1998.  Aromatic hydrocarbon receptor polymorphism: development of new methods to correlate genotype with phenotype.  Environ. Health Persp.  106: 421-426.

Mcarleton, C., A. Maier and K.A. Poirier.  2001.  Persistent Environmental Contaminants.  In:  Environmental Health Secrets, L.K. Williams and R. L. Langley, editors.  Hanley & Belfus, Inc., Philadelphia, PA.

Meek, M.E., J. Patterson, J. Strawson, and R. Liteplo.  2007.  Engaging Expert Peers in the Development of Risk Assessments.  Risk Anal.  27(6):1609-1621.  The definitive version is available at www.blackwell-synergy.com. An errata to the original published article is available here.  A prepublication copy is available here

Meek, B., A. Renwick, E. Ohanian, M. Dourson, B. Lake, B. Naumann and V. Vu.  2001.  Guidelines for application of compound specific adjustment factors (CSAF) in dose/concentration response assessment.  Comments on Toxicology. 7(5-6):575-590.  

Moore, M.M., R.H. Heflich, L.T. Haber, B.C. Allen, A.M. Shipp, and R.L. Kodell.  2007.  Analysis of in vivo Mutation Data Can Inform Cancer Risk Assessment.  Reg. Toxicol. Pharmacol.  In press..

Naumann, B., B. Meek, M.L. Dourson, and E. Ohanian.  2005.  The Future of Chemical Specific Adjustment Factors in Risk Assessment.  Risk Policy Report. 12(31): 14.

Nolen, G., W. Gibson, J. Benedict, D. Briggs and J. Schardein.  1985.  Fertility and Teratogenicity Studies of Diethylene Glycol Monobutyl Ether in Rats and Rabbits, Fundamental and Applied Toxicology 5, 1137-1143.

O'Flaherty, E.J. and M.L. Dourson. 1982. Relationship between urethane dose rate and adenoma latency: Relevance of tumor growth rate and target cell number. J. Natl. Cancer. Inst. 69(4): 859-865.

Patterson, J.,  P.J. Hakkinen, P. M. Nance, M. D. Dourson and B.J. Klauenberg.  2004.  Riot Control Agents: Issues in Toxicology, Safety, and Health by Eugene J. Olajos (Editor), W. Stopford (Editor)  Chapter 13: An Approach for Assessing and Characterizing Risk from Use of Riot Control Agents pages 259-271.

Patterson, J., P.J. Hakkinen and A.E. Wullenweber. 2002.  Human Health Risk Assessment: Selected Internet and World Wide Web Resources.  Toxicol. 173: 123-143.

Patterson, J., R. Schoeny and P. Daunt. 1991. The U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS). In: Regulating Drinking Water Quality. C. Gilbert and E. Calabrese, ed. Lewis Publishers, Inc., Chelsea, MI. 273-281.

Pittinger, C.A., T.H. Brennan, D. Badger, P.J. Hakkinen and M.C. Fehrenbacher.  2003.  Aligning Chemical Assessment Tools Across the Hazard-Risk Continuum.   Risk Analysis.  23(3): 529-535.

Price, P., R. Keenan, J. Swartout, C. Gillis, H. Carlson-Lynche and M. Dourson. 1997. An Approach for Modeling Noncancer Dose Responses with an Emphasis on Uncertainty. Risk Anal. 17 (4):427-437.

Puga A, J. Marlowe, S. Barnes, C. Chang, A. Maier, Z. Tan, J.K. Kerzee, X. Chang, M. Strobeck, E.S. Knudsen.  2002.  Role of the aryl hydrocarbon receptor in cell cycle regulation.  Toxicology. 27: 171-7.

Puga, A., S.J. Barnes, T.P. Dalton, C.Y. Chang, E.S. Knudsen, A. Maier.  2000.  Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest J. Biol. Chem.  275: 2943-50.

Ruoff, W.L., G.L. Diamond, S.F. Velazquez, W.M. Stiteler and D.J. Gefell. 1994. Bioavailability of cadmium in food and water: A case study on the derivation of relative bioavailability factors for inorganics and their relevance to the reference dose. Reg. Tox. Pharmacol. 20:139-160.

Scheuplein, R., G. Charnley and M.L. Dourson.  2002.  Differential sensitivity of children and adults to chemical toxicity:  I.  Biological Basis.  Reg. Tox. Pharmacol.  35:429-447.

Schoeny, R., L. Haber, and M. Dourson.  2006.  Data considerations for regulation of water contaminants. Toxicology. 221 (2-3): 217-224.

Schoeny, R., J. Patterson, J. Swartout and L. Tuxen. 1990. The U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS). In: Mutation and the Environment, Part E. Wiley-Liss, Inc. 257-266.

Stara, J.F., R.J.F. Bruins, M.L. Dourson, L.S. Erdreich, R.C. Hertzberg, P.R. Durkin and W.E. Pepelko. 1987. Risk assessment is a developing science: Approaches to improve evaluation of single chemicals and chemical mixtures. In: Methods for Assessing the Effects of Mixtures of Chemicals, V.B. Vouk, G.C. Butler, A.C. Upton, D.V. Parke and S.C. Asher, Ed. 1987 SCOPE. pp 719-743.

Stara, J.F., J. Patterson and M.L. Dourson. 1986. Risk assessment approaches for ground water contamination by pesticides and other organic substances. In: ACS Symposium Series: Evaluation of pesticides in Ground Water, W.Y. Garner, R.C. Honeycutt, H.N. Nigg, Ed. American Chemical Society, Washington, DC.

Stara, J.F., R.C. Hertzberg, R.J.F. Bruins, M.L. Dourson, P.R. Durkin, L.S. Erdreich and W.E. Pepelko. 1985. Approaches to risk assessments of chemical mixtures. In:  Karger Continuing Education Series Vol. 8: Safety Regulation of Chemicals in the U.S.A. S. Karger AG: Basil.

Stara, J.F., J. Patterson, K. Blackburn, R.C. Hertzberg and C.T. DeRosa. 1985. Health Risk Assessment of Chemical Mixtures. In: Trace Substances in Environmental Health - XIX. (D. Hemphill, Ed.) Proc. of the U-Missouri 19th Ann. Conf. on Trace Substances in Environmental Health, Columbia, MO June 3-6, 1985. p. 134-148.

Stara, J.F., D. Mukerjee, R. McGaughy, P. Durkin and M. Dourson. 1983. The current use and studies on promoters and cocarcinogens in quantitative risk assessment. Environ. Health Perspect. 50: 359-368.

Stara, J., M. Dourson and C.T. DeRosa. 1980. Water quality criteria: Applications. In: Conference Proceedings on Environmental Risk Assessment: How New Regulations Will Affect the Utility Industry, New Orleans, LA, Dec. 10-11. Prepared for the Electric Power Research Institute, Palo Alto, CA.

Stern, B.R., M. Solioz, D. Krewski, P. Aggett, T.-C. Aw, S. Baker, K. Crump, M. Dourson, L. Haber, R. Hertzberg,  C. Keen, B. Meek, L. Rudenko, R. Schoeny, W. Slob, T. Starr.  2007.  Copper and Human Health: Biochemistry, Genetics, and Strategies for Modeling Dose-response Relationships.  J. Toxicol. and Environ. Health, Part B 10(3):157-222.

Strawson, J., M. Dourson, Q. Zhao.  2005  The NAS Perchlorate Review:  Is the RfD Acceptable?  2005.  Env. Health Perspect 113(11):A729-30; Nov. Author reply A730-2.

Strawson, J., Q. Zhao and M. Dourson.  2004.  Reference dose for perchlorate based on thyroid hormone change in pregnant women as the critical effect.  Reg. Tox. and Pharm.  39: 44-65  
» Responses to perchlorate manuscript

Strawson, J., Q. Zhao and M. Dourson.  2004.  Response to Letter to the Editor.  "Critical Effect of Perchlorate on Neonates is Iodide Uptake Inhibition".  Reg. Tox  Pharmacol.  40:  378-379.

Swartout, J., P. Price, M.L. Dourson, H. Carlson-Lynch and R. Keenan. 1998. A Probabilistic Framework for the Reference Dose. Risk Analysis. Risk Analysis. 18(3): 271-282.

Stedeford T, Zhor J, Dourson ML, Banasik M, Hsu CH. 2007. The Application of Non-Default Uncertainty Factors in the U.S. EPA's Integrated Risk Information System (IRIS). Part I: UF(L), UF(S), and "Other Uncertainty Factors". J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 25(3):245-79.

Talaska, G., A. Maier, S. Henn, A. Booth-Jones, Y. Tsuneoka, R. Vermeulen, B. Schumann. 2002.  Carcinogen biomonitoring of human exposures and in laboratory research: validation and application to human occupational exposures. Toxicol. Letts. 134: 39-49.

Talaska, G., P. Underwood, A. Maier, J. Lewtas, N. Rothman, M. Jaeger.  1996.  Polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs and related environmental compounds: biological markers of exposure and effects.  Environ. Health Persp.  104(S5): 901-906.

Tao, X. G., H. G. Zhu, S. Z. Yu, Q.Y. Zhao, J. R. Wang, G. D. Wu, X. F. You, C. Li, W. L. Zhai, J. P. Bao and Z. Q. Sun. 1991-1992. Pilot study on the relationship between male stomach and liver cancer death and mutagenicity of drinking water in the Huangpu River area. Public Health Reviews 19(1-4):219-227.

Teuschler, L.K., M.L. Dourson, W.M. Stiteler, P. McClure and H. Tully.  1999.  Health risk above the reference dose for multiple chemicals.  Reg. Toxicol. And Pharmacol., 30: S19-S26.

Toraason et. al.  2002.  Improving Risk Assessment:  Toxicological Research Needs.  Hum. Ecol. Risk. Assess.  8(6): 1405-1419.

Wexler, P., Hakkinen, P., Nance, P., Parker, A, Patterson, J. 2007. The Information Infrastructure of Toxicology.  In: Principles and Methods of Toxicology. Ed. Hayes, A.W. 5th ed., CRC Press, Boca Raton, FL

Whitmyre, G., W. Dang, J. Driver, M. Eberhart, L. Fell, P.J. Hakkinen, M. Jaycock, P. Kennedy and T. Osimitz.  2001.  Consumer Products and Related Sources.   In: Residential Exposure Assessment.  A Sourcebook.  S. Baker, J. Driver and D. McCallum.  (editors). Kluwer  Academic/Plenum Publishers, New York, NY. pp. 201-244

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Wullenweber, A., et al..  2008.  Resources for global risk assessment: The International Toxicity Estimates for Risk (ITER)

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York, Raymond; Lewis, Elise; Brown, W.; Girard, Michael; Mattie, David; Funk, Kathleen; Strawson, Joan.  2005.  Refining the Effects Observed in a Developmental Neurobehavioral Study of Ammonium Perchlorate Administered Orally in Drinking Water to Rats. I. Thyroid and Reproductive Effects.  In:  International Journal of Toxicology, Volume 24, Number 6, Number 6/November-December 2005, pp. 403-418(16)

York, Raymond; Barnett, John; Girard, Michael; Mattie, David; Bekkedal, Marni; Garman, Robert; Strawson, Joan.  2005  Refining the Effects Observed in a Developmental Neurobehavioral Study of Ammonium Perchlorate Administered Orally in Drinking Water to Rats. II. Behavioral and Neurodevelopment Effects.  In:  International Journal of Toxicology, Volume 24, Number 6, Number 6/November-December 2005, pp. 451-467(17)

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York, R.G., W.R. Brown, M.F. Girard and J.S. Dollarhide.  2001.  Oral (drinking water) developmental toxicity study of ammonium perchlorate in New Zealand white rabbits.  International Journal of Toxicology.  20:199-205.

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Zhao, Qiyu , M. Dourson and B. Gadagbui.  2006.  A Review of the Reference Dose (RfD) for Chlorpyrifos.  Reg. Toxicol. Pharmacol. 44: 111-124 

 

Zhao, Q., B. Gadagbui and M. Dourson.  2005.  Lower birth weight as a critical effect of Chlorpyrifos: A comparison of human and animal data.  Reg. Toxicol. Pharmacol.  42: 55-63.

Zhao, Q.  2005Benchmark Dose.  In Encyclopedia of Toxicology.  Elsevier Inc. 246-248

Zhao, Q.  2004.  Software review of ToxTools for Windows (version 1.0).  Human and Ecological Risk Assessment. 10:609-614

Zhao, Q., H. Kan, L. Haber, B. Chen and M. Dourson.  2004.  Advance in Dose-Response Analysis.  Chinese J. Pharmacology and Toxicology.  18:152-160.  Chinese edition

Zhao, Q., J. Unrine and M.L. Dourson. 1999. Replacing the Default Values of 10 With Data-Derived Values: A Comparison of Two Different Data Derived Uncertainty Factors for Boron. Human and Ecological Risk Assessment. 5(5): 973-983.

Zhao, Q., L. Simpson, K. E. Driscoll and G. D. Leikauf. 1998. Chemokine regulation of ozone-induced neutrophil and monocyte inflammation. Am. J. Physiol. Lung Cell. Mol. Physiol. 274: L39-L46.

Framework for Metals Risk Assessment.  2007.  U.S. EPA Risk Assessment Forum.  EPA 120/R-07/001.  Several TERA staff were contributors.

TERA Reports…

Analysis of OEL recommendations for 1-bromopropane

Acrylonitrile: Inhalation Cancer Risk Assessment. Prepared for the Acrylonitrile Group by Toxicology Excellence for Risk Assessment. Final Document, v.2, February 1997.

Benchmark Concentration Modeling on the Effects of Acute Exposure to Methyl Isothiocyanate (MITC).  Prepared for AMVAC by Michael Dourson, Ph.D. and Melissa Kohrman, B.A. of Toxicology Excellence for Risk Assessment (TERA), Bruce Allen, M.S., and William Cain, Sc.M., Ph.D. of University of California.  November 1, 2007

Comparative Dietary Risks: Balancing the Risks and Benefits of Fish Consumption (Document in Adobe Acrobat)  Results of a cooperative agreement between TERA and the U.S. Environmental Protection Agency.  August 1999.

Development of Reference Doses and Reference Concentrations for LanthanidesPrepared for The Bureau of Land Management, National Applied Resource Sciences Center by Toxicology Excellence for Risk Assessment.  Amended Final, November 1999.

Evolution of Science-Based Uncertainty Factors in Noncancer Risk Assessment. Prepared for Health and Environmental Sciences Institute (HESI) by Toxicology Excellence for Risk Assessment. January 31, 1996.

Trimethylbenzene Toxicity Profile. Toxicity profile for US EPA, Office of Water. Critically reviewed and summarized the toxicokinetics, health effects in humans and animals, and the mechanism of toxicity from oral and inhalation exposure to trimethlbenzene. Identified likely critical effects, NOAEL and LOAEL for developing an RfD, and discussed data gaps in deriving the risk values.

Occupational Hazard Profile Documentation. Toxicological summary documents on methyl methacrylate, aluminum, and bentonite for NIOSH. These documents reviewed non-cancer and cancer health effects, as well as data on genotoxicity, reproductive and developmental effects, and toxicokinetics in both humans and animals following acute or chronic exposure.

Immediately Dangerous to Life or Health Review Document. Review document prepared for NIOSH. Reviewed and summarized acute toxicity of acrolein, chlorinated camphene, chloroacetaldehyde, carbon disulfide, and carbon monoxide in humans and animals after inhalation exposure. Discussed the likelihood of loss of life or permanent physical impairments, or substantial neurotoxic effects that would impair a worker's ability to escape at IDLH level based on available toxicity information, and critically evaluated the IDLH levels currently used by NIOSH for data quality and propriety

Health Risk Assessment/Characterization of the Drinking Water Disinfection Byproduct Chloroform. Prepared for U.S. Environmental Protection Agency, Office of Water by Toxicology Excellence for Risk Assessment. November 1998.

Toxicological Review Of Bromate In Support of Summary Information on the Integrated Risk Information System (IRIS), Prepared for the U.S. Environmental Protection Agency. September 22, 1998 The final document is now available on IRIS, at http://www.epa.gov/iris/subst/1002.htm

Toxicological Review Of Phenol In Support of Summary Information on the Integrated Risk Information System (IRIS), Prepared for the U.S. Environmental Protection Agency. September 2002. The final document is now available on IRIS, at http://www.epa.gov/iris/subst/0088.htm

Toxicological Review of Soluble Nickel Salts. Prepared for Metal Finishing Association of Southern California, Inc., U.S. Environmental Protection Agency, and Health Canada by Toxicology Excellence for Risk Assessment. March 1999.  Note that this has been substantially modified since this 1999 draft to reflect more recent data, and in response to EPA and external peer reviewer comments.

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