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Perchlorate
REPRODUCTIVE AND DEVELOPMENTAL TOXICITY
- Oral (drinking water) two-generation reproduction study in rats. Conducted by Argus Research Laboratory, Inc. in Horsham, Pennsylvania. Funded by the Perchlorate Study Group. This study evaluated the potential for perchlorate to cause reproductive effects and was designed to meet U.S. EPA testing guidelines. It reduces uncertainty associated with an incomplete database. Study has been completed and has been submitted to the U.S. EPA.
- Oral (drinking water) developmental toxicity in rabbits (Segment II). Conducted by Argus Research Laboratory, Inc. in Horsham, Pennsylvania. Funded by the Perchlorate Study Group. This study evaluates the potential for perchlorate to cause developmental effects and was designed to meet U.S. EPA testing guidelines. It reduces uncertainty associated with an incomplete database. The protocols for the dose range-finding study and full study are below. Study has been completed and has been submitted to the U.S. EPA.
- Study Protocol for Oral (Drinking Water) Dosage-Range Developmental Toxicity Study of Ammonium Perchlorate in Rabbits
- Study protocol for Oral (Drinking Water) Developmental Toxicity Study of Ammonium Perchlorate in Rabbits
- 1998 SOT Abstract
- Summary of Final Report
- Published Version of Development Toxicity in Rabbits
- Neurobehavioral Developmental Study in rats. Conducted by Argus Research Laboratory, Inc. in Horsham, Pennsylvania. Funded by the U.S. Air Force. The neurobehavioral developmental study was designed to meet U.S. EPA testing guidelines and addresses the potential for perchlorate to affect neurological development and learning after fetal/neonatal exposure. Study has been completed and submitted to the U.S. EPA.
- Hormone, Thyroid and
Neurohistological Effects in Pregnant and Lactating Rats
and in Fetuses and Nursing Pups. Conducted by
Argus Research Laboratory, Inc. in Horsham, Pennsylvania.
Funded by the Perchlorate Study Group. This study
evaluates the potential for perchlorate to cause
teratogenicity in a second species (rats) and measures
TSH, T4, and T3 changes in developing rats and adult
female rats during pregnancy and lactation. It also
measures neurohistological and thyroid effects at the
same time points and correlates these effects with
hormone concentration changes at different stages in the
development of the rat. Draft reports have been
submitted to U.S. EPA.
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Study Protocol for Hormone, Thyroid, and Neurohistological Effects of Oral (Drinking Water) Exposure to Ammonium Perchlorate in Pregnant and Lactating Rats and in Fetuses and Nursing Pups Exposed to Ammonium Perchlorate During Gestation or via Maternal Milk.
- Protocol 1416-003
- Histopathology of the Thyroid (Attachment 5)
- Brain Pathology Supplement (Attachment 6)
- Protocol Amendments
- Disposition of Reviewer Comments on Protocol
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Exposed Premating to Lactation Day 5 or 10
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Exposed Premating to Lactation Day 22
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- Published Version of Rat Developmental Toxicity Results
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- Effects of Pre- and Neonatal
Hypothyroidism Induced by Maternal Ammonium Perchlorate
on the Development of Motor Activity in Rat Pups.
Conducted by Naval Health Research Center Toxicology
Detachment, (Dayton, Ohio). Funded
by the U.S. Air Force. This study was designed
to help determine if increased motor activity is an
effect of perchlorate exposure. The study is designed to
meet U.S. EPA testing guidelines.
For further information, contact Ms. Joan Strawson at 910-692-7752 or Strawson@tera.org
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Phone: 513-542-7475
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Email: TERA@TERA.org
Last updated: 01/22/2008