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Perchlorate
IMMUNOTOXICITY
Effects of ammonium perchlorate on immunotoxicological, hematological, and thyroid parameters in B6C3F1 female mice. Conducted by the Medical University of South Carolina. Funded by a research grant from the U.S. Army. This immunotoxicity study addresses questions regarding the potential for perchlorate to alter the immune system, in addition to evaluating the effects of perchlorate on thyroid hormones and thyroid histology in mice. Mice were treated with perchlorate in the drinking water for either 14 or 90 days or for 90 days with a 30-day recovery period. A variety of immune parameters were evaluated including delayed type hypersensitivity following challenge by Listeria monocytogenes, cytotoxic T lymphocyte activity following challenge by P815 tumor cells, natural killer cell activity, macrophage phagocytosis, and numbers and distribution of immune cells. Contact Dr. Deborah Keil by phone at 803-792-3169 or email keilde@musc.edu for additional information regarding this study.
Ammonium Perchlorate: Effect on Immune Function. Conducted by Burleson Research Technologies, Inc. Raleigh, NC. Funded by the Perchlorate Study Group. This study was conducted at the request of U.S. EPA to provide additional information on immune function not evaluated by Dr. Keil in the above study. Mice were treated with perchlorate in drinking water for either 14 or 90 days. Immune function parameters measured were the plaque-forming cell response to sheep red blood cells, and delayed type hypersensitivity in the local lymph node assay. In addition, thyroid hormones, thyroid histology, and the ability of perchlorate to stimulate cell proliferation in thyroid cells were all evaluated. Study is complete and draft report has been submitted to U.S. EPA. Final report to be added after EPA risk assessment is released.
For further information, contact Ms. Joan Strawson at 910-692-7752 or Strawson@tera.org
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Last updated: 01/22/2008