|
|
Table 4. LOEL and BMD of T4 and TSH Changes in
Sub-chronic Animal Studies
(relative human doses mg/kg-day).
Species |
Study |
Time point |
LOAEL |
BMD10 |
BMD20 |
| T4 | |||||
| Male | |||||
| Rat | Siglin 1998 | 90 days | 0.0027 | 0.0019 | 0.0048 |
| P1 Rat | York 1999 | PND 21 | 8.0 | 5.8 | 7.4 |
| F1 Rat | York 1999 | PND 21 | 8.0 | N/A | N/A |
| Female | |||||
| Rat | Siglin 1998 | 90 days | 0.0027 | 4.4e-8 | 0.0024 |
| Mouse | BRT-Burleson Res. Tech. Inc. 2000 | 90 days | --- | --- | --- |
| Mouse | Keil et al. 1999 | 90 days | --- | --- | --- |
| TSH | |||||
| Male | |||||
| Rat | Siglin 1998 | 90 days | 0.053 | 0.014 | Out of range |
| P1 Rat | York 1999 | PND 21 | 8.0 | 2.3 | 2.9 |
| F1 Rat | York 1999 | PND 21 | 8.0 | 0.37 | 0.74 |
| Female | |||||
| Rat | Siglin 1998 | 90 days | 2.7 | 0.48 | 2.5 |
| Mouse | BRT-Burleson Res. Tech. Inc. 2000 | 90 days | --- | --- | --- |
| Mouse | Keil et al. 1999 | 90 days | --- | --- | --- |
Note: N/A = Not available because the data could not be
modeled.
--- = Result is available but needs to be approved by the study
authors.
© 2003 Toxicology Excellence for Risk Assessment
2300 Montana Avenue, Suite 409,
Cincinnati OH 45211
Phone: 513-542-7475
Fax: 513-542-7487
Email: TERA@TERA.org