|
|
Table 2. Summary of Human Studies
Study type |
Subject |
Sample size |
Exposure route |
Dose |
Exposure duration |
Reference |
| Acute exposure | Healthy males (25-28-y old) | 5 males | Oral | 3x300 mg a | N/A | Brabant et al., 1992 |
| Epidemiology | Workers (20-56-y old) | Total of 58 workers | Inhalation | 0.01, 0.29, 4.20 or 28.7 mg/dayb | 40% workers exposed for >5 years | Lamm et al., 1998 |
| Epidemiology | Perchlorate production workers (39.9-44.3-y old) | 120 controls, 26 low dose and 33 hi dose | Inhalation | 0.075, 3.4 or 28.6 mg/kgc | 5.8-11.9 years | Gibbs et al., 1998 |
| Epidemiology | Perchlorate production workers (10-46.9-y old) | 72 controls, 18 low dose and 31 hi dose | Inhalation | 0.093, 3.6 or 40.8 mg/kg | 7.3-14 years | Gibbs et al., 1998 |
| Epidemiology | Neonates (1.2-1.45 days after birth) | 5882 controls and 17308 exposed | During gestation (through mothers' drinking water) | 0 or 5.1 ug/l | Whole gestation | Li et al., 1999 |
Note:
a: The study authors did not report the detailed dosing procedure.
b: This was calculated from the perchlorate concentration (total particles) in the working environment, the assumption of an inhalation rate of 1.2 cubic meters per hour and duration of exposure.
d: This was calculated from the perchlorate inhalation concentration (total particles), respiratory rate (9.2 M3 over 8-hour shift or 13.9 M3 over a 12-hour shift), exposure duration and fraction absorbed [78% based on Boecker's study (1969) on CsCl].
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