Perchlorate

GENOTOXICITY

• Genotoxicity assay of ammonium perchlorate. Conducted by ManTech Environmental Technology, Inc. in Research Triangle Park, North Carolina. Funded by the Perchlorate Study Group. This study was to determine the potential genotoxicity associated with the exposure to ammonium perchlorate. Three studies were included: a Salmonella typhimurium reverse mutation assay, a mouse lymphoma mammalian cell gene mutation assay, and a micronucleus as in mice. The original, approved protocol was not followed completely. Below is the original protocol and also the protocol under which the study was completed. A repeat of the mouse lymphoma assay was conducted by BioReliance to address issues raised in the EPA review of the ManTech study. This work was also funded by the Perchlorate Study Group. Submitted to the U.S. EPA.

• Protocol for the Mantech Genotoxicity Assay of Ammonium Perchlorate
  As reviewed by protocol review panel, originally approved by TERA and the Perchlorate Study Group.
• Protocol for the Genotoxicity Assay of Ammonium Perchlorate (Revised)
  Protocol actually followed by Mantech Environmental Technology for the studies submitted to the U.S. EPA.
  • Justification for Protocol Revisions
    Explanation of changes made by the Mantech Environmental Technology.
• Final Report for First Study
• Protocol for BioReliance Study
• Final Report of BioReliance Study

For further information, contact Ms. Joan Strawson at 910-692-7752 or Strawson@tera.org

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Last updated:  01/22/2008

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