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Toxicology Excellence for
Risk Assessment (TERA)
2300 Montana Avenue, Suite 409, Cincinnati OH 45211
Phone: 513-542-7475
Fax: 513-542-7487
Email:
TERA@TERA.org
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Table 5. LOEL and BMD of T4 and TSH Changes in
Dams of Developmental
or 2-gen Studies (relative human doses mg/kg-day).
Species
|
Study
|
Time
point
|
LOEL
|
BMD10
|
BMD20
|
| T4 |
| Rat |
York 2000 |
GD21 |
--- |
--- |
--- |
| Rat |
York 2000 |
PND22 |
--- |
--- |
--- |
| Rabbit |
York 1998 |
Developmental |
14 |
0.13 |
2.7 |
| P1 Rat |
York 1999 |
PND 21 |
N/A |
N/A |
N/A |
| F1 Rat |
York 1999 |
PND 21 |
N/A |
N/A |
N/A |
| TSH |
| Rat |
York 2000 |
GD21 |
--- |
--- |
--- |
| Rat |
York 2000 |
PND22 |
--- |
--- |
--- |
| Rabbit |
York 1998 |
Developmental |
N/A |
N/A |
N/A |
| P1 Rat |
York 1999 |
PND 21 |
N/A |
N/A |
N/A |
| F1 Rat |
York 1999 |
PND 21 |
8.0 |
0.80 |
2.2 |
Note: N/A = not available because the data could not be
modeled.
--- = Result is available but needs to be approved by the study
authors.
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© 2004 Toxicology Excellence for Risk Assessment
2300 Montana Avenue, Suite 409, Cincinnati OH
45211
Phone: 513-542-7475
Fax: 513-542-7487
Email: TERA@TERA.org
Last updated: 01/22/2008
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