Toxicology Excellence for Risk Assessment (TERA)

2300 Montana Avenue, Suite 409, Cincinnati OH 45211
Phone: 513-542-7475
Fax: 513-542-7487

Email: TERA@TERA.org
 

Table 1. Summary of Animal Studies

Study

Species

Route of exposure

Dose

Exposure duration

Sample collection

Hormone testing lab

Reference
Short-term study Sprague-Dawley rats Drinking water 0, 0.1, 0.5, 1.0, 2.0, 3.0, 5.0, 10.0, and 25.0 mg/kg-day 14 days Blood samples were collected after 14 days of exposure WP Air Force Base. Caldwell et al., 1996.
Sub-chronic Study Mice Drinking water 0, 0.02, 0.06, 0.2, or 2.0 mg/kg-day 14 or 90 days Blood samples were collected after 14 and 90 days of exposure ManTech, Dayton, OH BRT-Burleson Res. Tech. Inc. 2000
Sub-chronic study Sprague-Dawley rats Drinking water 0, 0.01, 0.05, 0.2, 1.0, 10 mg/kg-day 14 or 90 days Blood samples were collected after 14 and 90 days of exposure ManTech Environmental Technology, Dayton, OH Siglin 1998
Sub-chronic study B6C3F1 female mice Drinking water 0, 0.1, 3.0, or 30.0 mg/kg-day 14 or 90 days Blood samples were collected on day 14, or 90. Medical University of South Carolina Keil et al., 1999
Developmental study Crl:CD(SD)IGS BR VAF/Plus rats Drinking water 0, 0.01, 0.1, 1.0, or 30.0 mg/kg-day 15 days before cohabitation and continuing through end of the study Dams were sacrificed on DG 21, and pubs were sacrificed on DG 21, PND 2 or PND 10 ManTech, Dayton, OH York 2000
Developmental study New Zealand White female rabbits Drinking water 0, 0.1, 1.0, 10.0, 30.0, or 100 mg/kg-day Gestation day 6 to 28 The animals were sacrificed on gestation day 29. AniLytics, Inc. York 1998
2-generation study Sprague-Dawley rats Drinking water 0, 0.3, 3.0 and 30.0 mg/kg-day 70 days before cohabitation and continue exposure through out the study period P1 and F1 adults were sacrificed at the end of 21-day postpartum period.

F1 and F2 pups were sacrificed on lactation day 21.

 AniLytics, Inc. York 1999
 

© 2004 Toxicology Excellence for Risk Assessment

2300 Montana Avenue, Suite 409, Cincinnati OH 45211
Phone: 513-542-7475
Fax: 513-542-7487
Email: TERA@TERA.org

Last updated:  01/22/2008

 

                                 © 2008 Toxicology Excellence for Risk Assessment