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Acetone VCCEP Peer Consultation Panel
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Below is the list of Core panel members and additional panelists for the Acetone VCCEP Peer Consultation. Click on each panel member's name to go directly to their biographical sketch.
Ms. Nicole Cardello until recently was a staff scientist with the Physicians Committee for Responsible Medicine (PCRM), a non-profit organization that promotes nonanimal experimental methods in medical and scientific research. As a scientist with PCRM, she reviewed every test plan submitted under EPA’s High Production Volume (HPV) chemical-testing program. She has submitted technical reports describing the toxicity data and available exposure information for HPV chemicals. She also wrote articles for the quarterly journal, Good Medicine. Ms. Cardello previously worked as an environmental scientist for the U.S. EPA’s National Exposure Research Laboratory, where she evaluated the design, performance, and collection efficiency of a personal electrostatic precipitator for aerosol exposure studies, and as a research scientist at the Johns Hopkins School of Hygiene and Public Health, where she evaluated the collection efficiency of a bioaerosol sampler, developed a dermal exposure database for pesticides of public health concern, and investigated the physical properties of the skin that facilitate absorption. Ms.
Cardello received her M.H.S. in Environmental Health Science from
Johns Hopkins School of Hygiene and Public Health where her work
focused on environmental and occupational monitoring and the role
of exposure information in risk assessments and epidemiological
studies. She received
her B.S. in Environmental Science and Engineering from the Ms. Cardello has served as part of an expert panel for the U.S. EPA’s Workshop on Characterizing and Presenting Chemical Exposure Assessment Results, and participated in the EPA/ACC Technical Workshop for Exposure Assessment under the Voluntary Children’s Chemical Evaluation Program (VCCEP). She is a member of the International Society of Exposure Analysis. Dr. George Daston is a Research Fellow for the Procter & Gamble Company where he has worked since 1985. He has worked the past 21 years in the field of developmental toxicology and risk assessment, particularly in the area of children’s risk assessment. Dr.
Daston is also an adjunct professor in the Department of
Pediatrics and Developmental Biology Program at the Dr.
Daston received his Ph.D. in Developmental Biology and Teratology
and a B.S. in Biology from the His research interests include teratogenic mechanisms, in vitro methodologies, and risk assessment. His most recent research includes toxicant-nutrient (especially zinc) and maternal-embryonal interactions in developmental toxicity, the role of pattern formation genes in abnormal development, genomic approaches to endocrine disrupter screening, and improvements in risk assessment methodology for non-cancer endpoints. Dr. Daston's activities in professional societies include serving as Chair of the Reproductive and Developmental Effects Subcommittee of the American Industrial Health Council, Chair of the Developmental and Reproductive Toxicology Technical Committee of ILSI-Health Effects Sciences Institute; President of the Society of Toxicology's Reproductive and Developmental Toxicology Specialty Section, President of the Teratology Society, member of the National Academy of Sciences Board on Environmental Studies and Toxicology, and member of EPA's Endocrine Disrupter Screening and Testing Advisory Committee (EDSTAC). Dr. Daston has recently served on the organizing committees for an ILSI/EPA/AIHC workshops on benchmark dose methodology and human variability in toxic response; an EPA workshop on endocrine-mediated toxicity; and as co-chair of an AIHC/EPA workshop on Leydig cell tumors, an ILSI/EPA workshop on interpreting reproductive toxicity endpoints, and a NIEHS workshop on the state of validation of the FETAX assay for teratogen screening. Dr. Daston is an Associate Editor of Toxicological Sciences, Editor-in-Chief of Birth Defects Research Part B: Developmental and Reproductive Toxicology, on the Editorial Board of Human and Ecological Risk Assessment and Reproductive Toxicology, and an ad hoc reviewer for Teratology, Journal of Nutrition and other journals. He has published over 90 peer-reviewed articles, reviews and book chapters, and has edited three books. Dr. Michael Dourson directs Toxicology Excellence for Risk Assessment (TERA), a nonprofit corporation dedicated to the best use of toxicity data for estimating risk assessment values. TERA's projects include the development of complex risk assessments, such as soluble nickel salts; research into improvements of risk methods, such as differential sensitivity of children and adults to chemical toxicity, organizing peer review and consultation meetings for risk assessment topics and documents; and education and outreach on risk assessment values through lectures and data bases, including the International Toxicity Estimates for Risk (ITER). Before founding TERA in 1996, Dr. Dourson held leadership roles in the U.S. Environmental Protection Agency for fifteen years; as chair of EPA's Reference Dose (RfD) Work Group, charter member of the EPA's Risk Assessment Forum and chief of the group that helped create the Integrated Risk Information System (IRIS) in 1986. Dr. Dourson received his Ph.D. in Toxicology from the Dr. Dourson’s research interests include investigating methods to extrapolate toxicity data garnered on experimental animals or healthy adults to the appropriate sensitive human population. Topic such as adversity of effect, and characterization of risk are also of interest. Dr. Dourson has served on numerous expert panels, such as EPA’s peer review panels for IRIS assessments and its Risk Assessment Forum, TERA’s International Toxicity Estimates for Risk (ITER) independent peer reviews and consultations, FDA’s Science Board Subcommittee on Toxicology, the NSF’s Health Advisory Board, and SOT’s harmonization of cancer and non-cancer risk assessment. Dr. Dourson has also organized over 16 symposia for 9 different organizations on a variety of topics, including: effective risk communication; chromium; information resources for toxicology and environmental health; risk assessment of essential trace elements; risk characterization; EPA’s IRIS; role of toxicology in tomorrow’s risk assessment practice; techniques for quantifying uncertainty in risk assessment; statistical and dose response models in risk assessment; workshop on benchmark dose methodology; basics of risk assessment; improvements in quantitative noncancer risk assessment; and neurotoxicity risk assessment. Dr. Dourson is a Diplomate of the American Board of Toxicology and served on its Board as President, Vice President and Treasurer. He is currently Secretary for the Society for Risk Analysis. He has also served as president of the Dose-Response Specialty Group of the Society for Risk Analysis, of the Society of Toxicology's Specialty Section on Risk Assessment and of the Ohio Chapter of the Society for Risk Analysis. He is currently on the editorial board of three journals. Dr Dourson has published more than 70 papers on risk assessment methods, has co-authored over 100 government risk assessment documents, and has made over 90 invited presentations.
Dr. Michael L. Gargas, Ph.D., Managing Principal of The Sapphire Group™, is a toxicologist with over 26 years of related environmental experience. Dr. Gargas oversees and prepares human health risk assessments, conducts toxic tort support investigations, serves as an expert witness, interacts with regulatory agencies, and addresses critical toxicological issues through applied and basic research on behalf of clients. His clients include private industry, trade associations, law firms, regulatory agencies, and private citizens. Dr. Gargas’ area of expertise is in human health risk assessment and biochemical toxicology research with emphasis in the areas of inhalation toxicology, chemical metabolism, physiologically based pharmacokinetic (PBPK) modeling, and chemical dosimetry, with specific application of these approaches to risk assessments. Prior to joining The Sapphire Group™, Dr. Gargas served as a Principal Health Scientist with ChemRisk (a risk assessment and toxicology consulting firm), a senior research scientist at the Chemical Industry Institute of Toxicology (CIIT), and as a toxicology research scientist with the U.S. Air Force (as a civilian) and the U.S. Navy (on active duty). Dr. Gargas completed undergraduate degrees in Medical Laboratory Technology and Biology from George Washington University and Wright State University, respectively and his doctorate in Biomedical Sciences (Toxicology Specialty) is from Wright State University. Dr. Gargas has been honored by the Society of Toxicology with the Frank R. Blood Award, the Department of the Air Force Invention/Patent Award (Co-Inventor) for an In Vivo Dermal Absorption System for Rats, Invention No. 15, 859 (U.S. Patent Number: 4,582,055) and the Outstanding Technical Civilian of the Year Award, from the Air Force Aerospace Medical Research Laboratory. Dr. Gargas has held or currently holds memberships in the Society of Toxicology and the Society for Risk Analysis and has served on the editorial board of Toxicology and Applied Pharmacology. Dr. Gargas has been invited to present numerous guest lectures on toxicology and risk assessment topics and is an Adjunct Assistant Professor of Toxicology at Wright State University, serving as director for a graduate course in biokinetics and toxicology. Dr. Gargas has conducted toxicology research on numerous volatile organic compounds (VOCs) including benzene, toluene, styrene, xylenes, furan, ethylene, ethylene oxide, glycol ethers, butadiene, acrylonitrile, the halogenated methanes, ethanes, and ethylenes, as well as the non-volatiles 2,3,7,8-tetrachlorodibenzo-p-dioxin, chromium, and Pb. He has been involved in a number of international seminars and conferences as a member of the organizing group and has close contacts with regulators in many parts of the world including the USA, Canada, and Europe. He has also published numerous book chapters and publications on a wide range of health and toxicologic topics.
Dr.
Elaine Hubal is a chemical engineer for the U.S. EPA’s National
Exposure Research Laboratory working in that lab’s human
exposure research program studying children’s residential
exposures to environmental contaminants.
Her research is on reducing uncertainty in risk assessment
with a specific focus on children’s exposure.
She is developing exposure factor data to reduce reliance
on default parameters in risk assessment.
She previously worked as a chemical engineer for the
Research Triangle Institute, and Dr.
Hubal received her Ph.D. and M.S. in Chemical Engineering from Dr. Hubal has served on a variety workgroups, panels, and committees. She currently serves as a member of the Interagency Dosimetry Working Group, EPA’s Risk Assessment Forum Children’s Exposure Technical Panel, the American Chemistry Council’s Human Exposure Assessment Technical Implementation Panel, and the Study Design Working Group for the National Children’s Study. She was an invited participant to the NERL Dermal Exposure Workshop, Outdoor Residential Task Force Workshop, ILSI Aggregate Exposure Assessment Model Evaluation and Refinement Workshop, the Chemical Manufacturer’s Association’s Exposure Workshop, and the EPA/ACC Technical Workshop for the Voluntary Children’s Chemical Evaluation Program (VCCEP). Dr. Hubal’s current research interest is designing studies to evaluate dermal exposure assessment approaches and collect exposure factor data in support of the Food Quality Protection Act. She has worked on the development of a modeling platform to predict contaminant fate and transport of environmental pollutants to perform exposure assessments in support of the Hazardous Waste Identification Rule, developed and worked with a variety of computational models to describe the simultaneous mass transport and reaction of inhaled gases in the airway lining, and conducted research in the area of industrial pollution prevention by developing a framework to evaluate the environmental impact of pollution prevention activities which directly relates to the energy requirements to process air, water, and solid waste emissions. Dr. Hubal has published in the areas of children’s exposure and human health risk modeling. Dr.
Sam Kacew is a professor in the Department of Cellular and
Molecular Medicine, Faculty of Medicine, as well as a scientist of
the Dr.
Kacew received his Ph.D. in Pharmacology from the Dr.
Kacew has served on dozens of expert panels and committees,
including as a member of the National Advisory Committee on
Environmental Contaminants and the Implications for Child Health,
and as a member of the National Academy of Sciences of the He has presented hundreds of invited lectures for a variety of federal and state government agencies, colleges and universities, private companies, and international organizations. He was an invited participant to the American Society for Pharmacology and Experimental Therapeutics Meeting, the Federation of American Societies for Experimental Biology Annual Meeting, the International Life Sciences Institute, the Chalk River Nuclear Labs, Turkey Society of Biochemistry and the Korea Society of Toxicology. Dr. Kacew is on a number of grant committees and has served as an external referee for grants and fellowships for a wide variety of organizations and government agencies. He is currently the Editor-in-Chief the Journal of Toxicology and Environmental Health, an Associate Editor for Toxicology and Applied Pharmacology, an assistant editor for TOMES (Micromedex, Inc.), as well as a member of the editorial board of a number of other journals. Dr. Kacew has over 140 publications in peer-reviewed journals and books in the area of toxicology, risk assessment, and children’s health. He has also served as an editor for a number of books on toxicology and children. Dr.
Richard Reiss is a Vice President at Sciences International, Inc.
(Sciences), a health and environmental consulting firm in Dr. Reiss has
expertise in both air quality and chemical risk assessment,
including human health and ecological risk issues.
He has published articles and reports, and given technical
presentations on all of these issues.
He has conducted research in urban and indoor air quality
and provides consulting services to governmental and industrial
organizations for urban air quality, industrial hygiene, and air
toxics issues. Dr. Reiss also consults with numerous organizations and companies on
chemical fate and transport, and exposure.
He has conducted risk assessments, data analyses,
probabilistic exposure modeling and environmental exposure
modeling for environmental agents, such as pesticides, industrial
chemicals, consumer product chemicals, and asbestos.
He has expertise in the use of mathematical models for
conducting advanced exposure assessments.
He also performs statistical analyses, including
dose-response modeling to evaluate chemical toxicity.
He has directed the development of data for new and
existing products to better understand potential human health and
environmental effects associated with chemicals. Dr.
Reiss is the Managing Editor of Risk
Analysis: An International Journal, the leading scholarly
journal for risk analysis. He
was the winner of the 2001 Chauncey Starr award from the Society
for Risk Analysis. This
award recognizes a risk analyst less than 40 years of age that has
made major contributions to the field of risk analysis.
He also served as the
chair of the Exposure Assessment Specialty Group of the Society
for Risk Analysis.
Dr.
Jennifer Seed is a Branch Chief with the She
provides supervision and leadership to a staff of scientists with
expertise in toxicology, epidemiology, biostatistics, and
ecotoxicology. This
branch is responsible for developing human health hazard and risk
assessments, toxicology and ecotoxicology test guidelines in
support of OECD harmonization efforts Dr. Seed also worked as a biologist for the Health and Environmental Review Division, where she conducted human health hazard and risk assessments of environmental chemicals regulated under the TSCA. She developed and reviewed Agency risk assessment guidelines for reproductive toxicity and testing guidelines for assessing developmental neurotoxicity for OPPT and OPP, as well as developing and teaching courses on developmental neurotoxicity for U.S. EPA and other agencies. She helped develop OPPT’s children’s health strategy In addition to her work at EPA, Dr. Seed also served as a senior scientist for ILSI Risk Science Institute where she developed and managed teams of scientists from academia, industry, and government charged with resolving issues in toxicology and risk assessment. From 1996 to 1997 she worked as a private consultant on toxicology and risk assessment projects Dr.
Seed received her Ph.D. in Developmental and Cellular Biology and
a B.A. in Anthropology (minor in Biology) from the Dr. Seed has served on a variety of committees, panels, and workgroups. She currently serves on the U.S. EPA’s Risk Assessment Forum, as well as the RfD/RfC technical Panel that is responsible for reviewing the methods used by the agency in developing RfD/RfCs to ensure that children and other susceptible subpopulations are adequately protected and on the FQPA 10x workgroup that is developing the implementation policy of the FQPA 10x factor to ensure adequate protection of children’s health. Dr. Seed served as a member of the U.S. EPA’s Reference Dose Workgroup and co-chaired the Reproductive and Developmental Toxicity Harmonization Workgroup, as well as served as the Chair of the international OECD team to develop a guidance document for reproductive toxicity and as an OPPT representative for the ORD/OPPTS Toxics/Pesticides Research Coordination Team. She has also served on the ILSI steering committee for behavioral developmental toxicity project, scientific advisor for the ILSI Residue Technical Committee, co-chaired the ILSI working group on skeletal variations and children’s health risk assessment, SOT steering committee for a workshop on harmonization of risk assessment for cancer and noncancer endpoints, OECD’s working group for developmental neurotoxicity guidelines, and EPA’s Technical Panel on Framework for Human Health Risk Assessment. Dr. Seed has published in the area of developmental and reproductive toxicity and human health risk assessment, and has contributed to a number of EPA test guidelines and other documents. Dr. Kimberly M. Thompson is Assistant Professor of Risk Analysis and Decision Science in the Department of Health Policy and Management at the Harvard School of Public Health. She is the Director of the Kid Risk Project that seeks to improve the lives of children by using analytical methods to characterize children's risks and strategies to reduce those risks. Dr. Thompson directs a professional education course on Probabilistic Risk Analysis: Assessment, Management, and Communication, and she seeks to effectively integrate technological, social, political, legal, and economic issues into risk analyses that inform public policy and improve decision making. Her research interests focus on the issues related to developing and applying quantitative methods for risk assessment and risk management, and consideration of the public policy implications associated with including uncertainty and variability in risk characterization. Over the last decade, for both private and public clients Dr. Thompson has consulted on computer applications, projects concerning environmental quality, fate and transport of toxic chemicals in the environment, analysis of remedial alternatives at landfills and abandoned sites, efforts to characterize uncertainty and variability in risks, and development of white papers for the EPA on topics related to children’s risks. Dr. Thompson’s most recent consulting includes work with the MIT Lincoln Laboratory as part of an integration team studying the development of a national health surveillance and biodefense system, and her recent book Overkill focuses on microbiological risks in what she calls this “Age of Risk Management.” Dr.
Thompson received a Sc.D. in Environmental Health from Dr. Thompson has written over 30 peer-reviewed journal publications in the areas of human health modeling, probabilistic risk assessment, children’s health and risk communication. She has also reviewed manuscripts for over a dozen journals, including the Journal of Toxicology and Environmental Health, Risk Analysis, Health Policy, and the Journal of the American Medical Association.
Dr. Karla Thrall is currently the Technical Lead and Staff Scientist in the Biological Sciences Division at Battelle, Pacific Northwest Division where she has worked since 1992. Dr. Thrall received a Ph.D. in Toxicology from Dr. Thrall’s research interests are primarily in the development and experimental validation of physiologically based pharmacokinetic (PBPK) models to describe the absorption, distribution, metabolism and elimination of chemicals in the human body. She is associated with the Pacific Northwest
Association of Toxicologists, the Society of Toxicology, and the
American Industrial Hygiene Association, and is an Adjunct
Professor in the Environmental Science program at
Dr. Rebecca Tominack is one of the medical
directors of the Prior
to joining academia, Dr Tominack held various positions relating
to product and environmental stewardship in the corporate
headquarters of Monsanto Company in She
earned a degree in pharmacy from the Dr.
Tominack is board certified in Internal Medicine and in Medical
Toxicology. She is a Fellow of the Dr. Tominack has consulted to agencies of the state and federal governments as well as the International Program of Chemical Safety of the World Health Organization. She lectures frequently on toxicology subjects.
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