Toxicology Excellence for Risk Assessment (TERA)

2300 Montana Avenue, Suite 409, Cincinnati OH 45211
Phone: 513-542-7475
Fax: 513-542-7487

Email: TERA@TERA.org

Independent Peer Review 
for Captan Reclassification
List of Key References

1) Allen, S.L. (1994). Captan: Investigation of Duodenal Hyperplasia in mice.  Zeneca Toxicology Laboratory, Alderley Park Macclesfield, Cheshire , UK , Report No. CTL/L/5674.   2) Bernard, B.K., Gordon, E.B. (2000). An evaluation of the common mechanism approach to the Food Quality Protection Act: Captan and four related fungicides, a practical example.  Int. J. Toxicol. 19:43-61.   3) Chidiac, P., Goldberg, M.T. (1987). Lack of induction of nuclear aberrations by captan in mouse duodenum.  Environ. Mut. 9:297-306.   4) Daly, I.W., Knezevich, A. (1983).  A lifetime oral oncogenicity study of captan in mice. Biodynamics Laboratories, Report Number: 80-2491. Chevron Chemical Company. April 6, 1983 .  MRID 00126845.   5) Foster, J.R. (1994).  Captan: Second Investigation of Duodenal Hyperplasia in Mice. Unpublished report. Report No CTL/L/6022. Study No. PM0981. Zeneca Central Toxicology Laboratory, Alderley Park Macclesfield, Cheshire , U.K.   6) Foster, J.R., Elliot, B.M. (2000). Position Paper on the Significance of the Apparent Increase in the Incidence of Rat Tumors in Long Term Studies with Captan. Report No CTL/R/1461. Central Toxicology Laboratory, Alderley Park Macclesfield, Cheshire , U.K.   7) Gordon, E.B. (2001).  Captan and Folpet.  In: Handbook of Pesticide Toxicology, Volume 2, Academic Press.  pp 1711-1742.   8) NCI (1977). Bioassay of captan for possible carcinogenicity.  National Cancer Institute, Carcinogenesis Technical Report Series No. 15, CAS No. 133-06-2.  DHEW Publication No. (NIH) 77-815, Bethesda .   9) NOASR (1983).  Life-span oral carcinogenicity study of Merpan (captan) in rats.  Netherlands Organization for Applied Scientific Research.  EPA Accession No. 252722-32.   10) Pavkov (1985). Identification of a preneoplastic alteration following dietary administration of captan technical to CD-1 mice.  Stauffer Chemical Company Report T-11007, September 23, 1985 . EPA accession number 259578.   11) Provan, W.M., Eyton-Jones, H., Lappin, G.J., Pritchard, D.J., Moore , R.B., Green, T., (1995). The incorporation of radiolabelled sulphur from captan into protein and its impact on a DNA binding Study. Chemico-Biological Interactions 96:173-184.   12) Tinston, D.J. (1995), Captan: Investigation of Duodenal Hyperplasia in Mice. Unpublished Report. Zeneca Agrochemicals Report No. CTL/P/4532. Study No. PM0981. Central Toxicology Laboratory, Alderley Park , Macclesfield , U.K.   13) Tinston, D.J. (1996). Captan: A Time Course Study of Induced Changes in the Small Intestine and Stomach of the Male CD1 Mouse. Zeneca Report No. CTL/P/4893. Study No. PM1005. Central Toxicology Laboratory, Aderley Park , Macclesfield , U.K.   14) USEPA (1999). Captan: Reregistration Eligibility Decision (RED). U.S. Environmental Protection Agency, EPA 738-R-99-015, Washington , D.C. 15) Warner, M.L., Jefferson , M.D., Blair, M. (1982).  Two-year oral toxicity/carcinogenicity study of captan in rats.  International Research and Development Corp., Report No. 153-097.  Stauffer Chemical Company, Richmond , CA .  EPA Accession No. 249335-38. 16) Wong, O., Harris, F.,  (2000). An Epidemiologic Study of Workers Employed at a Captan Manufacturing Facility in Ohio .  Report submitted to Tomen Agro, Inc., September, 2000.