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What: Peer
Consultation
When: October 8-9, 2007
Where: Northern Kentucky University Metropolitan
Education and Training Services (METS)
Toxicology Excellence for Risk Assessment (TERA)
convened a peer consultation on a methodology called Quantitative
Composition Activity Relationship (QCAR) October 8-9, 2007.
The PAC Analysis Task Group (TG) of the Petroleum HPV Testing Group
proposed new methodology to predict the toxicity of untested petroleum
substances based on the relationship between polycyclic aromatic
compound (PAC) profile of petroleum substances and select mammalian
toxicity responses. The TG has named this methodology ‘Quantitative
Composition Activity Relationship’ or ‘QCAR.’ The goal of the
methodology is to predict dose levels of untested substances that will
produce a pre-defined change for selected repeat-dose and developmental
toxicity endpoints. The TG proposes to use these calculated values in
place of empirically-derived Lowest Observed Adverse Effect Levels (LOAELs)
in partial fulfillment of the TG’s data commitments in the EPA’s High
Production Volume (HPV) Chemical Challenge Program.
Peer Consultation Meeting Report
Revised Document (March 31, 2008)
After the peer consultation, the Task group updated and revised their document to respond to the peer consultation. Future updates are planned.
Subject Documents for Peer Consultation (August, 2007)
Volume 1 - Description on
US HPV Program
Volume 2-Investigation
into the Relationship between PAC Content & Acute, Repeat-Dose,
Development, & Reproductive Tox of Petroleum
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