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Cadmium Nephrotoxicity in Human Populations
TERA has won a grant from the US EPA/National Center for Environmental Assessment to evaluate whether and how cadmium toxicity differs with population character. Several RfCs are derived from occupational studies. There are concerns, however, that the worker population may not adequately represent the general population. This is both because of the "healthy worker effect," in which only those who are sufficiently healthy to do physical labor remain on the job, and because of the "hardened worker effect", in which some workers may adapt behaviorally or physiologically to continuous exposures. The objective of the study is to quantitatively compare the dose response in occupational studies and studies conducted in the general population. This project will use the rich human database for cadmium, which includes data on cadmium nephrotoxicity for workers, the general public, and for women only to address differences in population sensitivity. Toxicokinetic modeling will be used to calculate a consistent dose metric across studies (which include reporting of external exposure levels, cadmium concentration in the kidney, urinary cadmium), and the dose response from different populations is being compared.
For more information contact Dr. Lynne Haber at 513-542-7475, extension 17 or Haber@tera.org
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