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Comparison of NOAEL/LOAEL, Benchmark Dose, and Categorical Regression
The benchmark dose (BMD) approach is an alternative to the traditional NOAEL/LOAEL approach that has a number of advantages, including not being limited to the experimental doses, and responding appropriately to sample size and the associated uncertainty. A growing number of recent assessments have been developed using the BMD approach. Another dose-response modeling approach is categorical regression, which uses meta-analytical techniques to incorporate not only information on how the incidence of response increases with dose, but also information on how the severity of response increases with dose. Categorical regression can also be used to combine data across studies, or across endpoints, although the implications for risk assessment of applying categorical regression are less fully understood that they are for using the BMD approach. In this project for EPA’s Office of Water, the three approaches are being applied to the assessments of chloral hydrate and nitrate/nitrite. Comparisons of the three approaches will illuminate their strengths and weaknesses.
For more information, contact Dr. Lynne Haber at 513-542-7475, extension 17 or Haber@tera.org.
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