What is Dose-Response
Assessment Boot Camp?
It is
a new initiative providing
intensive, in-depth hands-on training in hazard characterization and
dose-response assessment for human
health risk assessments.
This week-long course with emphasis on dose response assessment is based
on our popular chemical risk assessment training sessions developed and
presented to various audiences in the past decade.
It is designed to provide systematic training in current
assessment practices as well as in the latest methods in human
health chemical risk assessments.
The course is for beginners through experienced toxicological
risk assessors who
wish to learn advanced methods and
enhance their understanding and skills in the basics.
The students will learn all aspects of hazard characterization
and dose response assessment, and practice the skills learned in the
classroom.
Upon completing the course, the participants will be able to derive and
evaluate risk values and supporting documentation for non-cancer and
cancer risk assessments and will receive a certificate documenting their
successful completion of the course. Five Certification Management
(CM) points are available from the American Board of Industrial
Hygienists (ABIH).
It is also worth 4 Continuing Education Units
(CEU).
Current Courses
Who should attend?
-
Risk assessors and toxicologists who conduct and write chemical
assessments
-
Risk assessors and toxicologists who review chemical assessments
-
Risk managers or policymakers who use the results of chemical
assessments and want to fully understand the processes involved in
risk value development
Participant
requirements - participants should have:
-
A basic understanding of toxicology
-
An interest in developing their skills in human
health risk assessment
What you will learn
1.
Non-cancer and Cancer Risk Assessment Principles
and Methods:
Learn how to critically
analyze effect data, understand toxicokinetic data and their use in
understanding mode of action (MOA) and developing risk values. Learn how
to incorporate uncertainty factors, utilize frameworks for considering
MOA and human
relevance, and learn information synthesis approaches for hazard
characterization and critical study
identification, and calculation of risk values for non-cancer
(e.g., reference doses or tolerable intakes) and cancer endpoints (e.g.,
cancer slope factors). Learn the latest methodologies used in
dose-response assessment.
2.
Dosimetric Adjustment Methods in Dose Response:
Learn how to develop interspecies
oral dose adjustments for
non-cancer and cancer assessment, cancer unit risk or slope factor
conversion, inhalation exposure
concentration unit conversion, and human
equivalent concentration (HEC) calculation for particle and vapor
exposure using various modeling
approaches. Applications of
the results of physiologically-based pharmacokinetic (PBPK) modeling
will also be introduced.
3.
Benchmark Dose (BMD) Modeling and Application in
Risk Assessment:
Learn how to do BMD modeling for non-cancer and cancer dose-response
assessments and get hands-on experience using the latest EPA software.
Learn how to appropriately
apply BMD modeling, choose models
and parameters, select data and run
models, and select the appropriate BMD as a point of departure in
a human health risk assessment.
The course addresses all of the models in the EPA software,
including dichotomous continuous,
cancer, and nested models.
4.
Principles for the Application of
Uncertainty Factors and Chemical Specific
Adjustment Factor (CSAF) Methodology:
Learn the concept of uncertainty factors and how they are used in
non-cancer risk and safety assessment by USEPA and other
organizations, and how data are used to
support values other than defaults.
Learn how to develop and use CSAFs according to the methods of
the
International Programme on Chemical Safety (IPCS), which includes the
use of mechanistic and toxicokinetic data to replace default uncertainty
factors for interspecies
extrapolation and intraspecies variability in deriving risk values such
as RfDs and Tolerable Concentrations (TCs).
5.
Comprehensive Risk Assessment Practice with Peer Review:
Learn
to develop, present and review a comprehensive non-cancer and cancer
assessment for a complex sample chemical over the course of the entire
week.
Look at the
Frequently Asked Questions for more details or
for more information, please contact Ms. Patricia Nance at
513-542-7475 x25 or nance@tera.org
or for specific course content contact Dr. Lynne Haber at 513-542-7475 x 17 or
haber@tera.org.
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