panel members are experts with sufficiently broad areas of
expertise to qualify them for service on most or all of the VCCEP
panels. Core panel
members add continuity to the peer consultation program and will
be asked to commit to serve on panels for one year.
brief biography is provided below for each of the 2004 panel members.
R. Jeffrey Lewis
ExxonMobil Biomedical Sciences, Inc.
George P. Daston
Ph.D. Developmental Biology and Teratology
The Procter & Gamble Company
Ph.D. Developmental and Cellular Biology
EPA, Risk Assessment Division
Michael L. Dourson
Toxicology Excellence for Risk Assessment
Elaine A. Hubal
Ph.D. Chemical Engineering
EPA, National Exposure Research Laboratory
Physicians Committee for Responsible Medicine
John Balbus is currently the Director of the Environmental Health
Program for Environmental Defense, where he is working on projects
related to antibiotic resistance, health impacts of urban sprawl
and transportation policy, and chemical testing and right-to-know.
Prior to his current position, he served as the founding
Director of the Center for Risk Science and Public Health, as well
as an Associate Professor at the
. Dr. Balbus’
research activities at the Center for Risk Science and Public
Health included addressing susceptibility in risk assessment and
risk management, children’s susceptibility to waterborne
contaminants, and health impacts of climate change.
Dr. Balbus was a founding co-director of the
for Children’s Health and the Environment, one of 11 Pediatric
Environmental Health Specialty Units funded by the USEPA and ATSDR.
Balbus received his M.D. from the
, an M.P.H. from the Johns Hopkins School of Hygiene and Public
Health, and an A.B. in Biochemistry from
. He completed
residencies in internal medicine at
and in occupational and environmental medicine at Johns Hopkins
School of Hygiene and Public Health.
Dr. Balbus has also held a variety of additional academic
appointments that include: Assistant Professor of Medicine at
, Clinical Fellow in Medicine at John Hopkins School of Medicine,
Assistant Professor in Medicine at
of the Health Sciences, and Clinical Instructor in Medicine at the
University of Pennsylvania School of Medicine.
Balbus is currently certified by the American Board of Internal
Medicine, and the American Board of Preventive Medicine, specialty
in Occupational Medicine.
addition to Dr. Balbus’s extensive professional and academic
career, he has published numerous articles relating to a variety
of topics in risk assessment, public health, and environmental
George Daston is a Research Fellow for the Procter & Gamble
Company where he has worked since 1985.
He has worked the past 21 years in the field of
developmental toxicology and risk assessment, particularly in the
area of children’s risk assessment.
Daston is also an adjunct professor in the Department of
Pediatrics and Developmental Biology Program at the
and Children's Hospital Research Foundation, and lectures in
courses on teratology, developmental biology, toxicology, and risk
Daston received his Ph.D. in Developmental Biology and Teratology
and a B.S. in Biology from the
. Prior to joining
the Procter & Gamble Company, Dr. Daston worked for the U.S.
EPA’s Health Effects Research Laboratory as a National Research
Council Research Associate and as an assistant professor for the
Department of Biological Sciences at the
research interests include teratogenic mechanisms, in
vitro methodologies, and risk assessment.
His most recent research includes toxicant-nutrient
(especially zinc) and maternal-embryonal interactions in
developmental toxicity, the role of pattern formation genes in
abnormal development, genomic approaches to endocrine disrupter
screening, and improvements in risk assessment methodology for
Daston's activities in professional societies include serving as
Chair of the Reproductive and Developmental Effects Subcommittee
of the American Industrial Health Council, Chair of the
Developmental and Reproductive Toxicology Technical Committee of
ILSI-Health Effects Sciences Institute;
President of the Society of Toxicology's Reproductive and
Developmental Toxicology Specialty Section, President of the
Teratology Society, member of the National Academy of Sciences
Board on Environmental Studies and Toxicology, and member of EPA's
Endocrine Disrupter Screening and Testing Advisory Committee (EDSTAC).
Daston has recently served on the organizing committees for an
ILSI/EPA/AIHC workshops on benchmark dose methodology and human
variability in toxic response; an EPA workshop on
endocrine-mediated toxicity; and as co-chair of an AIHC/EPA
workshop on Leydig cell tumors, an ILSI/EPA workshop on
interpreting reproductive toxicity endpoints, and a NIEHS workshop
on the state of validation of the FETAX assay for teratogen
Daston is an Associate Editor of Toxicological
Sciences, Editor-in-Chief of Birth Defects
Research Part B: Developmental and Reproductive Toxicology,
on the Editorial Board of Human
and Ecological Risk Assessment and
Reproductive Toxicology, and an ad hoc reviewer for Teratology,
Journal of Nutrition
and other journals. He
has published over 90 peer-reviewed articles, reviews and book
chapters, and has edited three books.
Dr. Michael Dourson directs Toxicology
Excellence for Risk Assessment (TERA), a nonprofit
corporation dedicated to the best use of toxicity data for
estimating risk assessment values.
TERA's projects include the development of complex
risk assessments, such as soluble nickel salts; research into
improvements of risk methods, such as differential sensitivity of
children and adults to chemical toxicity, organizing peer review
and consultation meetings for risk assessment topics and
documents; and education and outreach on risk assessment values
through lectures and data bases, including the International
Toxicity Estimates for Risk (ITER).
Before founding TERA
in 1996, Dr. Dourson held leadership roles in the U.S.
Environmental Protection Agency for fifteen years; as chair of
EPA's Reference Dose (RfD) Work Group, charter member of the EPA's
Risk Assessment Forum and chief of the group that helped create
the Integrated Risk Information System (IRIS) in 1986.
Dr. Dourson received his Ph.D. in Toxicology from the
and a B.A. in biology from
Dr. Dourson’s research interests include
investigating methods to extrapolate toxicity data garnered on
experimental animals or healthy adults to the appropriate
sensitive human population. Topic
such as adversity of effect, and characterization of risk are also
Dr. Dourson has served on numerous expert
panels, such as EPA’s peer review panels for IRIS assessments
and its Risk Assessment Forum, TERA’s
International Toxicity Estimates for Risk (ITER)
independent peer reviews and consultations, FDA’s Science Board
Subcommittee on Toxicology, the NSF’s Health Advisory Board, and
SOT’s harmonization of cancer and non-cancer risk assessment.
Dr. Dourson has also organized over 16
symposia for 9 different organizations on a variety of topics,
including: effective risk communication; chromium; information
resources for toxicology and environmental health; risk assessment
of essential trace elements; risk characterization; EPA’s IRIS;
role of toxicology in tomorrow’s risk assessment practice;
techniques for quantifying uncertainty in risk assessment;
statistical and dose response models in risk assessment; workshop
on benchmark dose methodology; basics of risk assessment;
improvements in quantitative noncancer risk assessment; and
neurotoxicity risk assessment.
Dr. Dourson is a Diplomate of the American Board of Toxicology
and served on its Board as President, Vice President and
Treasurer. He is
currently Secretary for the Society for Risk Analysis.
He has also served as president of the Dose-Response
Specialty Group of the Society for Risk Analysis, of the Society
of Toxicology's Specialty Section on Risk Assessment and of the
Ohio Chapter of the Society for Risk Analysis. He is currently on
the editorial board of three journals. Dr
Dourson has published more than 70 papers on risk assessment
methods, has co-authored over 100 government risk assessment
documents, and has made over 90 invited presentations.
Elaine Hubal is a chemical engineer for the U.S. EPA’s National
Exposure Research Laboratory working in that lab’s human
exposure research program studying children’s residential
exposures to environmental contaminants.
Her research is on reducing uncertainty in risk assessment
with a specific focus on children’s exposure.
She is developing exposure factor data to reduce reliance
on default parameters in risk assessment.
She previously worked as a chemical engineer for the
Research Triangle Institute, and
and McKee. She also
served as a Predoctoral Fellow at the Chemical Industry Institute
Hubal received her Ph.D. and M.S. in Chemical Engineering from
and a S.B. in Chemical Engineering from Massachusetts Institute of
Hubal has served on a variety workgroups, panels, and committees.
She currently serves as a member of the Interagency
Dosimetry Working Group, EPA’s Risk Assessment Forum
Children’s Exposure Technical Panel, the American Chemistry
Council’s Human Exposure Assessment Technical Implementation
Panel, and the Study Design Working Group for the National
Children’s Study. She
was an invited participant to the NERL Dermal Exposure Workshop,
Outdoor Residential Task Force Workshop, ILSI Aggregate Exposure
Assessment Model Evaluation and Refinement Workshop, the Chemical
Manufacturer’s Association’s Exposure Workshop, and the
EPA/ACC Technical Workshop for the Voluntary Children’s Chemical
Evaluation Program (VCCEP).
Hubal’s current research interest is designing studies to
evaluate dermal exposure assessment approaches and collect
exposure factor data in support of the Food Quality Protection
Act. She has worked
on the development of a modeling platform to predict contaminant
fate and transport of environmental pollutants to perform exposure
assessments in support of the Hazardous Waste Identification Rule,
developed and worked with a variety of computational models to
describe the simultaneous mass transport and reaction of inhaled
gases in the airway lining, and conducted research in the area of
industrial pollution prevention by developing a framework to
evaluate the environmental impact of pollution prevention
activities which directly relates to the energy requirements to
process air, water, and solid waste emissions.
Hubal has published in the areas of children’s exposure and
human health risk modeling.
Dr. Sam Kacew
Sam Kacew is a professor in the Department of Cellular and
Molecular Medicine, Faculty of Medicine, as well as a scientist of
responsibilities include teaching medical students and graduate
students the techniques required to write and publish peer-review
papers. His current
research involves the effects of chemical contaminants in breast
milk on infants, the role of confounding factors in toxicity
testing, as well as the basis for differences in responsiveness to
chemicals between infants and adults.
Kacew received his Ph.D. in Pharmacology from the
. He served as a
Postdoctoral Fellow for the Medical Research Council of Canada at
. Dr. Kacew was
certified in 1994 as a Fellow of Academy of Toxicological
Sciences. He has
received numerous awards, including several achievement,
recognition, public communications and travel awards from the
Society of Toxicology (SOT), the United States-China Foundation,
and the National Science Council of the Republic of China.
Kacew has served on dozens of expert panels and committees,
including as a member of the National Advisory Committee on
Environmental Contaminants and the Implications for Child Health,
and as a member of the National Academy of Sciences of the
, Committee on Toxicology. He
has also served as a chairman for a variety of symposiums, panels,
and committees including the SOT Annual Meeting’s General
Toxicology Session, the Federation of American Societies for
Experimental Biology Annual Meeting, an Assessment Panel for the
Canadian Council on Animal Care, a SOT Symposium on Use of
Moderate Dietary Restriction in Safety Assessment, and a SOT
Symposium on the Role of Diet and Obesity in Endocrine Disruption.
has presented hundreds of invited lectures for a variety of
federal and state government agencies, colleges and universities,
private companies, and international organizations.
He was an invited participant to the American Society for
Pharmacology and Experimental Therapeutics Meeting, the Federation
of American Societies for Experimental Biology Annual Meeting, the
International Life Sciences Institute, the Chalk River Nuclear
Labs, Turkey Society of Biochemistry and the Korea Society of
Kacew is on a number of grant committees and has served as an
external referee for grants and fellowships for a wide variety of
organizations and government agencies.
He is currently the Editor-in-Chief the Journal
of Toxicology and Environmental Health, an Associate Editor
for Toxicology and Applied
Pharmacology, an assistant editor for TOMES (Micromedex,
Inc.), as well as a member of the editorial board of a number of
other journals. Dr.
Kacew has over 140 publications in peer-reviewed journals and
books in the area of toxicology, risk assessment, and children’s
health. He has also
served as an editor for a number of books on toxicology and
Dr. R. Jeffrey
Lewis resigned from the VCCEP core on February 18, 2004 due to the
potential for a perceived conflict of interest with chemicals
anticipated to be discussed in 2004.
R. Jeffrey Lewis has been a Scientific Associate with ExxonMobil
Biomedical Sciences, Inc. since 1990.
He is responsible for designing and conducting
epidemiological studies of ExxonMobil employees, and advising the
Corporation regarding environmental health issues.
He also interacts with regulatory agencies regarding
1,3-butadiene, ethylene, and propylene scientific issues,
participates in scientific trade association activities, and
manages and plans research budgets and programs.
Dr. Lewis is also an Adjunct Assistant Professor of
Occupational Health at the
Lewis received his Ph.D. and a M.S. in Epidemiology from the
. He earned an M.B.A.
Lewis has over 15 years experience in designing, conducting,
analyzing, and publishing epidemiology studies.
He currently serves as the Chair for the Endocrine Group of
the Children’s Health Coordinating Group, the American Chemistry
Council’s Epidemiology Work Group, and the International
Institute of Synthetic Rubber Producer’s Epidemiology
Subcommittee. He is
also currently a member on the International Institute of
Synthetic Rubber Producer’s Environmental Health Committee.
He has served as a member on the European Center for
Ecotoxicology and Toxicology of Chemical’s Propylene Task Force,
as well as a organizing and editorial/publication committee member
for an international symposium on 1,3-Butadiene, Isoprene, and
Chloropene Health Effects in 2000.
Lewis is a current member of the
of Epidemiology, the Society for Epidemiological Research, and the
American Association for the Advancement of Science.
He has a variety of publications in the area of toxicology
and human health assessment.
Jennifer Seed is a Branch Chief with the
of Pollution Prevention and Toxics, Risk Assessment Division,
Existing Chemicals Assessment Branch of the U.S. EPA.
provides supervision and leadership to a staff of scientists with
expertise in toxicology, epidemiology, biostatistics, and
branch is responsible for developing human health hazard and risk
assessments, toxicology and ecotoxicology test guidelines in
support of OECD harmonization efforts
and alternatives to
animal testing through ICCVAM activities.
Dr. Seed serves on a number of EPA committees and
workgroups in these areas.
Seed also worked as a biologist for the Health and Environmental
Review Division, where she conducted human health hazard and risk
assessments of environmental chemicals regulated under the TSCA.
She developed and reviewed Agency risk assessment
guidelines for reproductive toxicity and testing guidelines for
assessing developmental neurotoxicity for OPPT and OPP, as well as
developing and teaching courses on developmental neurotoxicity for
U.S. EPA and other agencies.
She helped develop OPPT’s children’s health strategy
addition to her work at EPA, Dr. Seed also served as a senior
scientist for ILSI Risk Science Institute where she developed and
managed teams of scientists from academia, industry, and
government charged with resolving issues in toxicology and risk
assessment. From 1996
to 1997 she worked as a private consultant on toxicology and risk
Seed received her Ph.D. in Developmental and Cellular Biology and
a B.A. in Anthropology (minor in Biology) from the
. She served as a
Postdoctoral Fellow with the Department of Biochemistry,
Seed has served on a variety of committees, panels, and
currently serves on the U.S. EPA’s Risk Assessment Forum, as
well as the RfD/RfC technical Panel that is responsible for
reviewing the methods used by the agency in developing RfD/RfCs to
ensure that children and other susceptible subpopulations are
adequately protected and on the FQPA 10x workgroup that is
developing the implementation policy of the FQPA 10x factor to
ensure adequate protection of children’s health.
Dr. Seed served as a member of the U.S. EPA’s Reference
Dose Workgroup and co-chaired the Reproductive and Developmental
Toxicity Harmonization Workgroup, as well as served as the Chair
of the international OECD team to develop a guidance document for
reproductive toxicity and as an OPPT representative for the ORD/OPPTS
Toxics/Pesticides Research Coordination Team.
She has also served on the ILSI steering committee for
behavioral developmental toxicity project, scientific advisor for
the ILSI Residue Technical Committee, co-chaired the ILSI working
group on skeletal variations and children’s health risk
assessment, SOT steering committee for a workshop on harmonization
of risk assessment for cancer and noncancer endpoints, OECD’s
working group for developmental neurotoxicity guidelines, and
EPA’s Technical Panel on Framework for Human Health Risk
Seed has published in the area of developmental and reproductive
toxicity and human health risk assessment, and has contributed to
a number of EPA test guidelines and other documents.
Dr. Chad Sandusky is currently Director of
Research and senior toxicology advisor to the Physicians Committee
for Responsible Medicine (PCRM), a non-profit organization that
promotes nonanimal experimental methods in medical and scientific
research. For PCRM,
Dr. Sandusky coordinates the review and preparation of comments on
the EPA’s High Production Volume Challenge Program (HPV) and
Voluntary Children’s Chemical Evaluation Program (VCCEP)
chemical assessments. As such he stresses the weight-of- evidence
approach in these assessments and also the development of exposure
scenarios as key to the success of these programs.
He is actively engaged in identifying methods which use
alternatives to animal testing to meet the needs of the safety
assessments, including tests undergoing validation at the
for Alternative Methods (ECVAM) and the Interagency Coordinating
Committee on the Validation of Alternative Methods (ICCVAM).
Dr. Sandusky was the past Manager of
Toxicology and Risk Assessment at ENVIRON and has extensive
experience at both the EPA and ENVIRON in pesticide toxicology as
well as exposure and risk assessments. For
example, he evaluated the toxicology of pesticides and
extrapolated these effects in risk assessments; directed the
dietary exposure and risk assessments for agrichemicals and other
potentially toxic residues in foods using the TAS Dietary exposure
software; served as
toxicology team leader and senior author of numerous EPA
documents, including Registrations Standards and Position
Documents; and since the passage of the FQPA in August 1996,
coordinated the review and assessment of numerous agrichemicals to
address the full range of new requirements, including: assessing
aggregate exposure from multiple pathways (e.g., drinking water
and residential use), cumulative exposure from multiple pathways
from chemicals with a common mode of action, accounting for
potential sensitivity to infants and children, and assessing the
potential for endocrine disruption.
Dr. Sandusky has extensive international
experience including the coordination and submission of dossiers
for the EU Reauthorization process under EU 91/414 and
presentation of the results to member states.
Dr. Sandusky also represented the
at the Codex Committee for Pesticide Residues (CCPR) in
for several years. Dr.
Sandusky has also coordinated preparation and reviews of dossiers
for chemicals approved as GRAS through the GRAS –
self-affirmation process as well as directed the preparation and
submission of Food Contact Notifications (FCNs) to the FDA.
Dr. Sandusky received his Ph.D. in Pharmacology from the
. He served as a
Postdoctoral Fellow at the Georgetown University Schools of
Medicine and Dentistry,
He is currently a
member of the Society of Toxicology, and was previously affiliated
with such organizations as the International Society of Exposure
Analysis and the Society of Environmental Toxicology and
Kimberly M. Thompson
Kimberly M. Thompson is Assistant Professor of Risk Analysis and
Decision Science in the Department of Health Policy and Management
at the Harvard School of Public Health.
She is the Director of the Kid Risk Project that seeks to
improve the lives of children by using analytical methods to
characterize children's risks and strategies to reduce those
risks. Dr. Thompson
directs a professional education course on Probabilistic Risk
Analysis: Assessment, Management, and Communication, and she seeks
to effectively integrate technological, social, political, legal,
and economic issues into risk analyses that inform public policy
and improve decision making.
Her research interests focus on the issues related to
developing and applying quantitative methods for risk assessment
and risk management, and consideration of the public policy
implications associated with including uncertainty and variability
in risk characterization.
the last decade, for both private and public clients Dr. Thompson
has consulted on computer applications, projects concerning
environmental quality, fate and transport of toxic chemicals in
the environment, analysis of remedial alternatives at landfills
and abandoned sites, efforts to characterize uncertainty and
variability in risks, and development of white papers for the EPA
on topics related to children’s risks.
Dr. Thompson’s most recent consulting includes work with
the MIT Lincoln Laboratory as part of an integration team studying
the development of a national health surveillance and biodefense
system, and her recent book Overkill focuses on
microbiological risks in what she calls this “Age of Risk
Thompson received a Sc.D. in Environmental Health from
. She received a M.S.
and B.S. in Chemical Engineering from the Massachusetts Institute
of Technology. Dr.
Thompson has served on several National Academy of Sciences
committees and subcommittees and a number of other expert review
panels. She has been
an invited presenter at a variety of workshops, conferences, and
annual meetings, such as the Boston Mayor’s Symposium on Youth
Development, the Congressional Research Services’ Children’s
Environmental Risks: Federal
Activities in Perspective Symposium on Risk Assessment and Risk
Communication, and a NIH/NIEHS Workshop on the Role of Human
Exposure Assessment in the Prevention of Environmental Disease.
She also served as the chair of the Exposure Assessment
Specialty Group of the Society for Risk Analysis.
Thompson has written over 30 peer-reviewed journal publications in
the areas of human health modeling, probabilistic risk assessment,
children’s health and risk communication. She
has also reviewed manuscripts for over a dozen journals, including
the Journal of Toxicology and Environmental Health, Risk Analysis,
Health Policy, and the Journal of the American Medical