Peer Consultation on a Framework for Use of Quantitative Structure Activity Relationships
(QSAR) for Genotoxicity and Carcinogenicity
A panel of expert scientists conducted a written peer consultation to consider a draft
weight of evidence framework developed by the Existing Substances Division of Health
Canada for evaluating genotoxicity and carcinogenicity potential from empirical data
and (Q)SAR models. This draft framework was proposed as one element of Health Canada's
approach to categorization and screening of substances on the Domestic Substances List
(DSL) under the Canadian Environmental Protection Act. The panel also provided
input as a basis to refine the framework.
Note that the framework the panel discussed was not a finished product. It
was a proposal being presented at that time to access input from leading experts on how it
might be further developed as one element of an approach to efficiently set
priorities on the basis of hazard for large numbers of chemicals. The framework
and background materials were prepared by Health Canada.
The peer consultation was conducted through submission of written comments from the
Meeting Information and Documentation
For additional information, contact Dr. Andrew Maier at 513-542-7475 ext.