What is Dose-Response Assessment Boot Camp?  

It is a new initiative providing  intensive, in-depth hands-on training in hazard characterization and dose-response assessment for human health risk assessments. This week-long course with emphasis on dose response assessment is based on our popular chemical risk assessment training sessions developed and presented to various audiences in the past decade. It is designed to provide systematic training in current assessment practices as well as in the latest methods in human health chemical risk assessments.  The course is for beginners through experienced toxicological risk   assessors who wish to learn advanced methods and enhance their understanding and skills in the basics.  The students will learn all aspects of hazard characterization and dose response assessment, and practice the skills learned in the classroom.  Upon completing the course, the participants will be able to derive and evaluate risk values and supporting documentation for non-cancer and cancer risk assessments and will receive a certificate documenting their successful completion of the course.  Five Certification Management (CM) points are available from the American Board of Industrial Hygienists (ABIH).   It is also worth 4 Continuing Education Units (CEU).  Click here for a Boot Camp Brochure.

 

This course is endorsed by the Society of Toxicology (SOT).

And a recognized event by the Society for Risk Analysis (SRA).

 

Current Courses

 

September 19-23, 2011

 

The next course is September 19-23, 2011. The course hours are 8:00am - 5:00pm Monday - Thursday, and 8:00am - 2:00pm, Friday. There is also some evening work required (daily homework assignments). It will be held in Cincinnati, Ohio. The hotel location will be provided. Click here to download brochure.

 

Registration

 

To register for the course, you can complete the registration form found inside the brochure and then fax it to 513-542-7487 or you may register online by clicking here.

 

Course Fee

General (includes Federal Agencies).... $1,995
(After August 19, 2011—$2195)

State/City/County/Tribal Employee.... $1,495
(AfterAugust 19, 2011—$1695)

 

Course fee includes
• Tuition
• Take home reference binder
• Morning and afternoon breaks
• Certificate of completion

• 5 Certification Management Points from ABIH

• 4 continuing education credits (CEUs) with the National Environmental Health Association

Payment Policy
Registration is accepted on a first come, first serve basis. Full payment (in US funds) must be received in order to process your registration. To register, please mail or fax (513-542-7487) the enclosed registration form with credit card information or check/money order (payable to TERA) to: Boot Camp Registration, TERA, 2300 Montana Ave, Ste 409, Cincinnati, OH 45211. Please call 513-542- 7475 x 10 with questions.

 

Cancellation/Substitution Policy
Cancellations made on or before July 31, 2011 will be issued a refund less $150 administrative fee per person. Cancellations received between August 1, 2011 and August 19, 2011 will be issued a refund of 50%. No refunds will be issued after August 19, 2011. Substitutions are allowed with additional charge, but must be made by Friday, September 9, 2011. All requests for substitutions or cancellations must be made in writing via email to Patricia Nance at nance@TERA.org.

In the event the course is cancelled for the listed dates, registered attendees can either request a full refund of the course registration fee or apply it to the next course which would be schedule within 6-12 months of the original course date.

 

Accommodations

The course will be held off-site from the hotel.  Information on the course location will be made available shortly.  Transportation to the course will be provided, if needed.  We have a block of rooms at reduced rates at 2 hotels:

 

Hampton Inn & Suites/Uptown-University Area:  There are rooms available starting Sunday, September 18th thru Saturday, September 24th.  The room rate is $125/night (+tax), there are a limited number of government rate rooms available.  You must call to make reservations and ask for the group code is “TBC” or ask for the dates and the TERA Boot Camp block of rooms.  All reservations must be made by September 2, 2011.  Contact information for the hotel is Hampton Inn & Suites/Uptown-University Area, 3024 Vine Street, Cincinnati, Ohio 45219, Phone: (513) 281-2700 • fax (720) 223-7501

 

Kingsgate Marriott Conference Hotel at the University of Cincinnati:  There are rooms available starting Sunday, September 18th thru Saturday, September 24th.  The room rate is $148/night (+tax).  You must call to make reservations and ask for the group code is “TERA Room Block” (if needed the reference # is M-9LX84V).  All reservations must be made by September 2, 2011.  Contact information for the hotel is Kingsgate Marriott Conference Hotel at the University of Cincinnati, 151 Goodman Drive, Cincinnati, OH 45219, Phone: (513) 487-3800

 

 

Who should attend?

Risk assessors and toxicologists who conduct and write chemical assessments 

Risk assessors and toxicologists who review chemical assessments  

Risk managers or policymakers who use the results of chemical assessments and want to fully understand the processes involved in risk value development

 

Participant requirements

A basic understanding of toxicology    

An interest in developing their skills in human health risk assessment

 

What you will learn 

 

1.  Non-cancer and Cancer Risk Assessment Principles and Methods:  Learn how to  critically analyze effect data, understand toxicokinetic data and their use in understanding mode of action (MOA) and developing risk values. Learn how to incorporate uncertainty factors, utilize frameworks for considering MOA and human  relevance, and learn information synthesis approaches for hazard characterization and critical study identification, and calculation of risk values for non-cancer (e.g., reference doses or tolerable intakes) and cancer endpoints (e.g., cancer slope factors). Learn the latest methodologies used in dose-response assessment. 

 

 2.  Dosimetric Adjustment Methods in Dose Response:  Learn how to develop interspecies oral dose adjustments for non-cancer and cancer assessment, cancer unit risk or slope factor conversion, inhalation exposure concentration unit conversion, and human equivalent concentration (HEC) calculation for particle and vapor exposure using various modeling approaches.  Applications of the results of physiologically-based pharmacokinetic (PBPK) modeling will also be introduced. 

 

3.  Benchmark Dose (BMD) Modeling and Application in Risk Assessment:   Learn how to do BMD modeling for non-cancer and cancer dose-response assessments and get hands-on experience using the latest EPA software.  Learn how to appropriately apply BMD modeling, choose models and parameters, select data and run models, and select the appropriate BMD as a point of departure in a human health risk assessment.  The course addresses all of the models in the EPA software, including dichotomous continuous, cancer, and nested models.

 

4.  Principles for the Application of Uncertainty Factors and Chemical Specific Adjustment Factor (CSAF) Methodology: Learn the concept of uncertainty factors and how they are used in non-cancer risk and safety assessment by USEPA and other organizations, and how data are used to   support values other than defaults.  Learn how to develop and use CSAFs according to the methods of the International Programme on Chemical Safety (IPCS), which includes the use of mechanistic and toxicokinetic data to replace default uncertainty factors for interspecies extrapolation and intraspecies variability in deriving risk values such as RfDs and Tolerable Concentrations (TCs).   

 

5.  Comprehensive Risk Assessment Practice with Peer Review:  Learn to develop, present and review a comprehensive non-cancer and cancer assessment for a complex sample chemical over the course of the entire week.

 

 

Boot Camp Software

 

Below are the links for thesoftware you will need on your laptop for the Boot Camp Course. 


RDDR (zip file, although this is EPA software, it is older software and not available on the EPA website)

MPPD - http://www.ara.com/products/mppd.htm (this link takes you to a registration form that you must complete to receive an email with the link to the software)

U.S. EPA's Benchmark Dose Software (takes you to the USEPA's page for the software, you can register to receive updates or skip the registration)

 

 

Look at the Frequently Asked Questions for more details or for more information, please contact Ms. Patricia Nance at 513-542-7475 x25 or nance@tera.org or for specific course content contact Dr. Lynne Haber at 513-542-7475 x 17 or haber@tera.org.