TERA scientists combine a practitioner's knowledge of the issues and pitfalls involved in the development of human health risk assessments, together with cutting-edge toxicology expertise, to develop state-of-the-science assessments. Our research, aimed at improving risk assessment methods particularly in the areas of dose-response and mode of action, further enhances our analyses. In solving risk problems for a diverse array of government and private sponsors, we apply a collaborative philosophy that emphasizes partnership building, allowing us to expand our pool of expertise, build on multiple perspectives, and ensure the use of the best science. These strengths form the basis for our development of independent and science-driven analyses for a range of risk assessment needs. Our technical support areas include:
• Screening-level assessments and hazard and risk ranking
• Dossiers and Risk Assessments for HPV and REACH
• Occupational risk assessments, including OEL development
• Comprehensive in-depth evaluations for RfD/RfC derivation and cancer risk
• Risk methods and framework development in dose-response modeling, mixtures risk issues, mode of action evaluation techniques, and special issues such as children's risk.
The field of risk assessment is changing rapidly as the “omics” revolution and the burgeoning field of molecular toxicology provide a wealth of data that were not available with classical toxicology. TERA's research seeks to enhance the use of data on mode and mechanism of action to inform qualitative and quantitative aspects of risk assessment, by incorporating biomarker data to extend the dose-response curve, integrating “omics” information, and designing targeted studies to address key MOA questions. ...Learn more.
TERA has developed hundreds of toxicology reviews and risk assessment documents for our sponsors and the public. We use cutting-edge methods to address diverse needs, including assessments relevant to all major exposure pathways (inhalation, oral, and dermal) and exposure patterns (acute and chronic exposures) for single chemicals and mixtures. Our assessments include comprehensive assessments, screening and hazard assessments, and occupational risk assessments....Learn more.